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A4QFM5 (A4QFM5_CORGB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 RuleBase RU003664
EC=6.3.2.9 HAMAP MF_00639 RuleBase RU003664
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639
Ordered Locus Names:cgR_2042
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Subcellular location

Cytoplasm By similarity HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639 RuleBase RU003630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding125 – 1317ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
A4QFM5 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 681EC5DC916B6BD7

FASTA47249,283
        10         20         30         40         50         60 
MVSLSHLPQA LQGRILVAGA GVSGLSIAKM LSELHCDVVV ADDNETARHM LIEVVDVADI 

        70         80         90        100        110        120 
STAQAQEQLD SFSIVVTSPG WRPTSTLLVD AHRQGLEVIG DVELAWRLDQ AGVFGEPHTW 

       130        140        150        160        170        180 
LAVTGTNGKT TTTSMLAAMM NEGGFAAKAV GNIGIPVSEA LVAKNRIDVL VAELSSFQLH 

       190        200        210        220        230        240 
WSPTFTPDAG VVLNLAEDHI DWHGSMRDYA LAKMEVLKGK VAIIGADDPY LVQLTSEADL 

       250        260        270        280        290        300 
SGLIGFTVNE PATGQLGVKA GELVDNAYGN NVVLASADGI NPAGPAGVLD ALAAAAVARS 

       310        320        330        340        350        360 
QGVAPEAIAR ALDSFEVAGH RGQVVAEHDG VHFIDNSKAT NPHAADSALA GHDSVIWVVG 

       370        380        390        400        410        420 
GQLKGADIAP LVKKHEQRIK AALVLGADRA EIVAALKEHA PQASVFVTDK TEPFEAMEEI 

       430        440        450        460        470 
VTEAFSISEP GDTVLLAPAA ASLDMFKGMG QRGDLFAHNI IGTIKGLTEE KG

« Hide

References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF55041.1.
RefSeqYP_001138943.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QFM5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QFM5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4993592.
GenomeReviewsGene locus cgR_2042 in contig AP009044_GR.
KEGGcgt:cgR_2042.
PATRIC21508716. VBICorGlu58097_2104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBPRK00141.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4QFM5_CORGB
AccessionPrimary (citable) accession number: A4QFM5
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info