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A4QEY2

- PNP_CORGB

UniProt

A4QEY2 - PNP_CORGB

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, cgR_1804
Organism
Corynebacterium glutamicum (strain R)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi543 – 5431Magnesium By similarity
Metal bindingi549 – 5491Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCGLU340322:GJBE-1884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:cgR_1804
OrganismiCorynebacterium glutamicum (strain R)
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000006698: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329610Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340322.cgR_1804.

Structurei

3D structure databases

ProteinModelPortaliA4QEY2.
SMRiA4QEY2. Positions 17-743.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 66860KHAdd
BLAST
Domaini680 – 74970S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QEY2-1 [UniParc]FASTAAdd to Basket

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MSDVKYFEDT EFGLIEAVAT IDNGDFGTRT IRFETGQLAR QADGAVTTYL    50
DDDTMLLATT TASNQPREGF DFFPLTVDVE ERMYAAGRIP GSFFRREGRP 100
STEAILACRL IDRPLRPTFV KGLRNEVQIV VTVMSMNPED YYDVVAINGA 150
SAATRISGLP VSGAVGGVRM ALVVDEKHPE GQWVAFPTHA QHEQSVFEIV 200
VAGRLVERKR GNKTFSDVAV MMVEAGASEN VVNRVKDGAP APTEKIVSDG 250
LEAAKPFIDI LCRAQEGLAQ RVGNAAKEFP LFPPYTDEVY SAVERKVSKK 300
LASLLTLKAK QERDDATNAY MEEIEAELLP KFEASYSSAA EASKEIRAAY 350
NAVMKSIVRR MILTDHFRID GRGVTDIRDL AVEVELIPRA HGSSLFERGE 400
TQILGVTTLD MLKMEQQIDS LAPGDAKRYM HHYNFPPYST GETGRVGSPK 450
RREIGHGALA ERAVLPVIPS REEFPYSIRQ VSEALGSNGS TSMGSVCAST 500
LSLYNAGVPL KAPVAGIAMG LVSGEIDGKT EYVALTDILG AEDAFGDMDF 550
KVAGTADFIT ALQLDTKLDG IPSKVLSDAL EQARDARLTI LNTMADVING 600
PDEMSKFAPR ITTVKIPVAK IGELIGPKGK NINALTEETG ANISIEDDGT 650
VFISAADGAS AEAAIEKINA LANPQLPKVG ERFLGTVVKT TAFGAFVSLL 700
PGRDGLVHIS KLGNGKRVEK VDDVVKVGEK IQVEIADIDN RGKISLVPVA 750
EED 753
Length:753
Mass (Da):81,289
Last modified:May 15, 2007 - v1
Checksum:iF0BCC1FD338CBC5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009044 Genomic DNA. Translation: BAF54798.1.
RefSeqiYP_001138700.1. NC_009342.1.

Genome annotation databases

EnsemblBacteriaiBAF54798; BAF54798; cgR_1804.
GeneIDi4991706.
KEGGicgt:cgR_1804.
PATRICi21508218. VBICorGlu58097_1856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009044 Genomic DNA. Translation: BAF54798.1 .
RefSeqi YP_001138700.1. NC_009342.1.

3D structure databases

ProteinModelPortali A4QEY2.
SMRi A4QEY2. Positions 17-743.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340322.cgR_1804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF54798 ; BAF54798 ; cgR_1804 .
GeneIDi 4991706.
KEGGi cgt:cgR_1804.
PATRICi 21508218. VBICorGlu58097_1856.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CGLU340322:GJBE-1884-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
    Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
    Microbiology 153:1042-1058(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R.

Entry informationi

Entry nameiPNP_CORGB
AccessioniPrimary (citable) accession number: A4QEY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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