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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Corynebacterium glutamicum (strain R)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi543MagnesiumUniRule annotation1
Metal bindingi549MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:cgR_1804
OrganismiCorynebacterium glutamicum (strain R)
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000006698 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296101 – 753Polyribonucleotide nucleotidyltransferaseAdd BLAST753

Structurei

3D structure databases

ProteinModelPortaliA4QEY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini609 – 668KHUniRule annotationAdd BLAST60
Domaini680 – 749S1 motifUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QEY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVKYFEDT EFGLIEAVAT IDNGDFGTRT IRFETGQLAR QADGAVTTYL
60 70 80 90 100
DDDTMLLATT TASNQPREGF DFFPLTVDVE ERMYAAGRIP GSFFRREGRP
110 120 130 140 150
STEAILACRL IDRPLRPTFV KGLRNEVQIV VTVMSMNPED YYDVVAINGA
160 170 180 190 200
SAATRISGLP VSGAVGGVRM ALVVDEKHPE GQWVAFPTHA QHEQSVFEIV
210 220 230 240 250
VAGRLVERKR GNKTFSDVAV MMVEAGASEN VVNRVKDGAP APTEKIVSDG
260 270 280 290 300
LEAAKPFIDI LCRAQEGLAQ RVGNAAKEFP LFPPYTDEVY SAVERKVSKK
310 320 330 340 350
LASLLTLKAK QERDDATNAY MEEIEAELLP KFEASYSSAA EASKEIRAAY
360 370 380 390 400
NAVMKSIVRR MILTDHFRID GRGVTDIRDL AVEVELIPRA HGSSLFERGE
410 420 430 440 450
TQILGVTTLD MLKMEQQIDS LAPGDAKRYM HHYNFPPYST GETGRVGSPK
460 470 480 490 500
RREIGHGALA ERAVLPVIPS REEFPYSIRQ VSEALGSNGS TSMGSVCAST
510 520 530 540 550
LSLYNAGVPL KAPVAGIAMG LVSGEIDGKT EYVALTDILG AEDAFGDMDF
560 570 580 590 600
KVAGTADFIT ALQLDTKLDG IPSKVLSDAL EQARDARLTI LNTMADVING
610 620 630 640 650
PDEMSKFAPR ITTVKIPVAK IGELIGPKGK NINALTEETG ANISIEDDGT
660 670 680 690 700
VFISAADGAS AEAAIEKINA LANPQLPKVG ERFLGTVVKT TAFGAFVSLL
710 720 730 740 750
PGRDGLVHIS KLGNGKRVEK VDDVVKVGEK IQVEIADIDN RGKISLVPVA

EED
Length:753
Mass (Da):81,289
Last modified:May 15, 2007 - v1
Checksum:iF0BCC1FD338CBC5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF54798.1.
RefSeqiWP_011897394.1. NC_009342.1.

Genome annotation databases

EnsemblBacteriaiBAF54798; BAF54798; cgR_1804.
KEGGicgt:cgR_1804.
PATRICi21508218. VBICorGlu58097_1856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF54798.1.
RefSeqiWP_011897394.1. NC_009342.1.

3D structure databases

ProteinModelPortaliA4QEY2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF54798; BAF54798; cgR_1804.
KEGGicgt:cgR_1804.
PATRICi21508218. VBICorGlu58097_1856.

Phylogenomic databases

HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_CORGB
AccessioniPrimary (citable) accession number: A4QEY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.