A4QEQ9 (DXS_CORGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	cgR_1731

Organism

Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]

Taxonomic identifier

340322 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 632	632	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000019020

Sequences

	Sequence		Length	Mass (Da)
	A4QEQ9 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 8A5574648BBDF7C8	FASTA	632	67,458
	10 20 30 40 50 60 MGILNSISTP ADLKALNDED LDALAKEIRT FLVDKVAATG GHLGPNLGVV ELTIGLHRVF 70 80 90 100 110 120 DSPQDPIIFD TSHQSYVHKI LTGRAKDFDS LRQKDGLSGY TCRAESEHDW TESSHASAAL 130 140 150 160 170 180 SYADGLSKAK QLDGDTTHSV VAVVGDGALT GGMCWEALNN IAAGKDRKVV VVVNDNGRSY 190 200 210 220 230 240 SPTIGGFAEN LAGLRMQPFY DRFMEKGKTS LKSMGWVGER TFEALHAFKE GVKSTVIPTE 250 260 270 280 290 300 MFPELGMKYV GPVDGHNQKA VDNALKYAHD YDGPIIVHMV TEKGRGYAPA EQDLDELMHS 310 320 330 340 350 360 TGVIDPLTGA PKSASKPGWT SVFSDELVKI GAQNENVVAI TAAMAGPTGL SKFEANFPNR 370 380 390 400 410 420 FFDVGIAEQH AVTSAAGLAL GGKHPVVAIY STFLNRAFDQ LLMDVGMLNQ PVTLVLDRSG 430 440 450 460 470 480 VTGSDGASHN GVWDMALTSI VPGVQVAAPR DEDSLRELLN EAISIDDGPT VVRFPKGDLP 490 500 510 520 530 540 TPIVAIDTLE DGVDVLAYED ATEDDAPSVL IVAVGERATV ALEVASRITQ HGVNVTVVDP 550 560 570 580 590 600 RWIVPIPQSL VALSDDHDLV ITIEDGVIHG GVGSLLSDAL NASEVDTPRR QIAVPQKYLD 610 620 630 HASRSEVFAD YGLDADGIET TVVGWLDSLF GE

References

[1]

"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009044 Genomic DNA. Translation: BAF54725.1.
RefSeq	YP_001138627.1. NC_009342.1.
3D structure databases
ProteinModelPortal	A4QEQ9.
ModBase	Search...
Protein-protein interaction databases
STRING	A4QEQ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4994381.
GenomeReviews	Gene locus cgR_1731 in contig AP009044_GR.
KEGG	cgt:cgR_1731.
PATRIC	21508070. VBICorGlu58097_1782.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	QYDISYM.
ProtClustDB	PRK05444.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_CORGB

Accession

Primary (citable) accession number: A4QEQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program