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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Corynebacterium glutamicum (strain R)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei580 – 5801UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCGLU340322:GJBE-1707-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:cgR_1633Imported
OrganismiCorynebacterium glutamicum (strain R)Imported
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000006698: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi340322.cgR_1633.

Structurei

3D structure databases

ProteinModelPortaliA4QEF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QEF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFLRDDIR FLGRILGEVI AEQEGQEVYE LVEQARLTSF DIAKGNAEMD
60 70 80 90 100
SLVQVFDGIT PAKATPIARA FSHFALLANL AEDLHDEELR EQALDAGDTP
110 120 130 140 150
PDSTLDATWL KLNEGNVGAE AVADVLRNAE VAPVLTAHPT ETRRRTVFDA
160 170 180 190 200
QKWITTHMRE RHALQSAEPT ARTQSKLDEI EKNIRRRITI LWQTALIRVA
210 220 230 240 250
RPRIEDEIEV GLRYYKLSLL EEIPRINRDV AVELRERFGE DVPLKPVVKP
260 270 280 290 300
GSWIGGDHDG NPYVTAETVE YSTHRAAETV LKYYARQLHS LEHELSLSDR
310 320 330 340 350
MNKVTPQLLA LADAGHNDVP SRVDEPYRRA VHGVRGRILA TTAELIGEDA
360 370 380 390 400
VEGVWFKVFT PYASPEEFLN DALTIDHSLR ESNDTLIADD RLSVLISAIE
410 420 430 440 450
SFGFNLYSLD LRQNSESYED VLTELFERAQ VTANYRELSE EEKLEVLLKE
460 470 480 490 500
LRSPRPLIPH GSDEYSEVTD RELGIFRTAS EAVKKFGPRM VPHCIISMAS
510 520 530 540 550
SVTDVLEPMV LLLKEFGLIA ANGDNPRGTV DVIPLFETIE DLRAGAGILG
560 570 580 590 600
ELWKIDLYRN YLLQRDNVQE VMLGYSDSNK DGGYFSANWA LYDAELQLVE
610 620 630 640 650
LCRSAGVKLR LFHGRGGTVG RGGGPSYDAI LAQPKGAVQG SVRITEQGEI
660 670 680 690 700
ISAKYGNPET ARRNLEALVS ATLEASLLDV SELTDHQRAY DIMSEISELS
710 720 730 740 750
LKKYTSLVHE DQGFIDYFTQ STPLQEIGSL NIGSRPSSRK QTSSVEDLRA
760 770 780 790 800
IPWVLSWSQS RVMLPGWFGV GTALEQWIGE GEQATQRIAE LQTLNESWPF
810 820 830 840 850
FTSVLDNMAQ VMSKAELRLA KLYADLIPDR EVAERVYSVI HEEYFLTKKM
860 870 880 890 900
FCVITGSDDL LDDNPLLARS VQRRYPYLLP LNVIQVEMMR RYRKGDQSEQ
910 920
VSRNIQLTMN GLSTALRNSG
Length:920
Mass (Da):103,441
Last modified:May 15, 2007 - v1
Checksum:i265DDAF048E2E398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF54625.1.
RefSeqiWP_011897300.1. NC_009342.1.
YP_001138527.1. NC_009342.1.

Genome annotation databases

EnsemblBacteriaiBAF54625; BAF54625; cgR_1633.
GeneIDi4992877.
KEGGicgt:cgR_1633.
PATRICi21507862. VBICorGlu58097_1682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF54625.1.
RefSeqiWP_011897300.1. NC_009342.1.
YP_001138527.1. NC_009342.1.

3D structure databases

ProteinModelPortaliA4QEF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi340322.cgR_1633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF54625; BAF54625; cgR_1633.
GeneIDi4992877.
KEGGicgt:cgR_1633.
PATRICi21507862. VBICorGlu58097_1682.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciCGLU340322:GJBE-1707-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
    Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
    Microbiology 153:1042-1058(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RImported.

Entry informationi

Entry nameiA4QEF9_CORGB
AccessioniPrimary (citable) accession number: A4QEF9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: March 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.