ID   A4QED4_CORGB            Unreviewed;       909 AA.
AC   A4QED4;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=cgR_1608 {ECO:0000313|EMBL:BAF54600.1};
OS   Corynebacterium glutamicum (strain R).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=340322 {ECO:0000313|EMBL:BAF54600.1, ECO:0000313|Proteomes:UP000006698};
RN   [1] {ECO:0000313|Proteomes:UP000006698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R {ECO:0000313|Proteomes:UP000006698};
RX   PubMed=17379713; DOI=10.1099/mic.0.2006/003657-0;
RA   Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M.,
RA   Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.;
RT   "Comparative analysis of the Corynebacterium glutamicum group and complete
RT   genome sequence of strain R.";
RL   Microbiology 153:1042-1058(2007).
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DR   EMBL; AP009044; BAF54600.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4QED4; -.
DR   KEGG; cgt:cgR_1608; -.
DR   HOGENOM; CLU_317070_0_0_11; -.
DR   Proteomes; UP000006698; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..909
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002672527"
FT   TRANSMEM        886..907
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          97..382
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   DOMAIN          418..488
FT                   /note="Alpha-galactosidase NEW3"
FT                   /evidence="ECO:0000259|Pfam:PF10633"
FT   REGION          849..882
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        853..870
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   909 AA;  96616 MW;  A76B8223D31BD78F CRC64;
     MSRRKAVFSA LGAAALIGAA LPTIPTAQAQ TPTGYGFDAT ASIGEEPEFS TQQLADGGTL
     GFDCYRIPSL GVAPNGNVLA SWDGRPNNCS DAPQPNSIVG KVSTDNGATW GEQHDISAGI
     TAEPKTGYSD PSIVVDWERG DVFNFHVKSF DAGYFTSQPG TDPDDRNVAH VAYAKSSDNG
     STWVADTVIT DQVVADDTWD SRFATSGNGI QLQYGAYKGR LVQPSVTRMT NGRVAAVAML
     SDDHGTTWYP SAPWGNSMDE NKIVELSDGT LMNNSRSSGA DTYRKVSYST DGGVTWTEPT
     LDTQLPDPRN NASLIRVFPT APEGSAQAKV LLFSNTATTS GRTNGTVRMS CDDGQTWPVS
     KVFEPGAIQY TSMATLPNGD IGMLWENSGS NIDIFYSQFN LSWLEAGCIG VDADETPVTA
     GETTTMNVTL TNPFANAIFD RAVSLELPEG WQAEDVRVSI PSGESVTIPV QVTAPLVADN
     GELPVEVSIL DGADRYTGRL NLTVQGGQEP ASTSVKVSIP NLKDTYVAGE KISINFAVNN
     PFDVTVNSVP SLGEGENWMP ANLRGFDPEQ GAPNCRYRNL GANQSYNCTT TTYEVSDSDV
     ERGYVDIPTV WTFTNSAGET VWSKNVDVPR IELNGTQDAV TDAIVTVDPI NPVHSNGQSQ
     TVEVQANVTS EGDLPAGSKV AFYLDSSPID AAAVDAEGHA SISIDVDNIA SEQPERTFEV
     RARLVVPEDA PRSIARDALA RFTVLPEQVQ QNSLVIMNHP DVVSDGQTKT IVIAVKATAH
     DGSPVAIGTL ITFRVNGIER DVVPTNAQGT AKLQLDLKPV NTEDEEYEVT VEAELDELTA
     QTTFKVLAGE EEEPTSTEEQ PSETEQPSEP EEEPTAPTGS SNGGSFAALL ALLAALGGIV
     GAVLGLLKL
//