Reviewed, UniProtKB/Swiss-Prot A4QE91 (HIS2_CORGB)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-ATP pyrophosphatase
      Short name=PRA-PH
    EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	cgR_1565

Organism

Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]

Taxonomic identifier

340322 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_0000319645

Sequences

	Sequence		Length	Mass (Da)
	A4QE91-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: C25136A8FAA375D6	FASTA	90	10,241
	10 20 30 40 50 60 MYRVKTFDSL YEELLNRAQT RPEGSGTVAA LDKGIHHLGK KVIEEAGEVW IAAEYETDEE 70 80 90 LAGEISQLIY WTQVIMVARG LKPEDIYKNL

References

[1]

"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009044 Genomic DNA. Translation: BAF54557.1.
RefSeq	YP_001138459.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4QE91.
Genome annotation databases
GeneID	4993114.
GenomeReviews	Gene locus cgR_1565 in contig AP009044_GR.
KEGG	cgt:cgR_1565.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VWMAAEY.
Family and domain databases
HAMAP	MF_01020. [Tree]
InterPro	IPR008179. PRib-ATP_pyrophosphohydrolase. [Graphical view]
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
ProDom	PD002611. Pra_PH/CH. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03188. histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_CORGB

Accession

Primary (citable) accession number: A4QE91

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 15, 2007
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)