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A4QDZ5 (ARLY_CORGB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:cgR_1464
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Argininosuccinate lyase HAMAP MF_00006
PRO_1000000473

Sequences

Sequence LengthMass (Da)Tools
A4QDZ5 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: DA7C38B821194891

FASTA47751,084
        10         20         30         40         50         60 
MEQHGTNEGA LWGGRFSGGP SEAMFALSVS THFDWVLAPY DVLASKAHAK VLHQAELLSD 

        70         80         90        100        110        120 
EDLATMLAGL DQLGKDVADG AFGPLPSDED VHGAMERGLI DRVGPEVGGR LRAGRSRNDQ 

       130        140        150        160        170        180 
VATLFRMWVR DAVRDIALGT TELVDALSAQ AKAHADAIMP GKTHFQAAQP VLLAHQLLAH 

       190        200        210        220        230        240 
AQPLLRDIDR IRDLDKRLAV SPYGSGALAG SSLKLNPEAI AEELGFDSAA DNSIDATSSR 

       250        260        270        280        290        300 
DFASETAFVL AQLAVDMSRL AEEIIAWCTP EFGYITLSDS WSTGSSIMPQ KKNPDVAELT 

       310        320        330        340        350        360 
RGKSGRLIGN LTGLLATLKA QPLAYNRDLQ EDKEPIVDSV AQLNLLLPAM TGLVSTLTFN 

       370        380        390        400        410        420 
TERMRELAPA GFTLATDLAE WMVRQGVPFR EAHEASGACV RIAESRGVDL IDLTDEELSG 

       430        440        450        460        470 
VDARLTPEVR EVLTIDGAVA SRATRGGTAG VRVAEQRARV DAASTAHAEW ARAGVRR

« Hide

References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF54455.1.
RefSeqYP_001138357.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QDZ5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QDZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4992932.
GenomeReviewsGene locus cgR_1464 in contig AP009044_GR.
KEGGcgt:cgR_1464.
PATRIC21507510. VBICorGlu58097_1512.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_CORGB
AccessionPrimary (citable) accession number: A4QDZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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