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A4QDT4 (DDL_CORGB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:cgR_1395
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000030443

Regions

Domain149 – 353205ATP-grasp
Nucleotide binding176 – 23156ATP By similarity

Sites

Metal binding3081Magnesium or manganese 1 By similarity
Metal binding3201Magnesium or manganese 1 By similarity
Metal binding3201Magnesium or manganese 2 By similarity
Metal binding3221Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QDT4 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 5F11F6B39002831E

FASTA36038,593
        10         20         30         40         50         60 
MSNSNSGKVR VAVVYGGRSS EHSVSCVSAG AIMAHLDPEK YDVIPVGITV DGAWVVGETD 

        70         80         90        100        110        120 
PQKLTLIDRT MPEVEHREEV RPSLDPAHRG EFHFSDGSLY ATADVIFPVL HGRFGEDGTV 

       130        140        150        160        170        180 
QGLFALSDIP VVGPGVLASA AGMDKEYTKK LMAAEGLPIG REVILRDRTE LTEAEKNLLG 

       190        200        210        220        230        240 
LPVFVKPARG GSSIGISRVT AWEDFNKAVG LARAHDEKVI VESEIVGSEV ECGVLQYPDG 

       250        260        270        280        290        300 
RIVASVPALL SGTESGAGGF YDFDTKYLDN VVTAEIPAPL DEKTTELIQS LAVESFQALA 

       310        320        330        340        350        360 
CEGLARVDFF VTANGPVLNE INTMPGFTPI SMYPQMFTAS GVAYEELLDV LVQQALHRDN 

« Hide

References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009044 Genomic DNA. Translation: BAF54381.1.
RefSeqYP_001138283.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QDT4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340322.cgR_1395.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF54381; BAF54381; cgR_1395.
GeneID4992223.
KEGGcgt:cgR_1395.
PATRIC21507348. VBICorGlu58097_1432.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycCGLU340322:GJBE-1456-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_CORGB
AccessionPrimary (citable) accession number: A4QDT4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways