A4QCW5 (COAA_CORGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	cgR_1086

Organism

Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]

Taxonomic identifier

340322 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Pantothenate kinase HAMAP MF_00215		PRO_1000058631
Regions
	Nucleotide binding	108 – 115	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A4QCW5 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: BF5B6E638E6EBF78	FASTA	323	36,322
	10 20 30 40 50 60 MAEQNAASTT GVKPSPRTPD FSPYLDFDRA QWRELRNSMP QVLTQKEVIE LRGIGENIDL 70 80 90 100 110 120 AEVAEVYLPL SRLIHLQVAA RQQLTAATET FLGTSPSTSV PFVIGVAGSV AVGKSTTARL 130 140 150 160 170 180 LQVLLQRWNS HPRVDLVTTD GFLYPGAELT RRGLMSRKGF PESYDQRALL RFVTDVKSGK 190 200 210 220 230 240 LEVNAPVYSH TAYDRVPGEF TTVRQPDILI VEGLNVLQTG PTLMVSDLFD FSVYVDARTE 250 260 270 280 290 300 DIEKWYIDRF LKLRDTAFRR PGAHFSHYAD MADPESIAVA RELWQSINLP NLVENILPTR 310 320 VRASLVLKKG SDHLVERVRM RKI

References

[1]

"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009044 Genomic DNA. Translation: BAF54062.1.
RefSeq	YP_001137964.1. NC_009342.1.
3D structure databases
ProteinModelPortal	A4QCW5.
SMR	A4QCW5. Positions 22-323.
ModBase	Search...
Protein-protein interaction databases
STRING	A4QCW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4993798.
GenomeReviews	Gene locus cgR_1086 in contig AP009044_GR.
KEGG	cgt:cgR_1086.
PATRIC	21506721. VBICorGlu58097_1125.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_CORGB

Accession

Primary (citable) accession number: A4QCW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program