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A4QCK4

- PUR9_CORGB

UniProt

A4QCK4 - PUR9_CORGB

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Corynebacterium glutamicum (strain R)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCGLU340322:GJBE-1018-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:cgR_0976
    OrganismiCorynebacterium glutamicum (strain R)
    Taxonomic identifieri340322 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000006698: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Bifunctional purine biosynthesis protein PurHPRO_1000096058Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340322.cgR_0976.

    Structurei

    3D structure databases

    ProteinModelPortaliA4QCK4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4QCK4-1 [UniParc]FASTAAdd to Basket

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    MSDDRKAIKR ALISVYDKTG LEDLAQALHR ENVEIVSTGS TAAKIAELGI    50
    PVTPVEELTG FPECLEGRVK TLHPKVHAGI LADTRKEDHL RQLKELEVAP 100
    FQLVVVNLYP FAETVASGAD FDACVEQIDI GGPSMVRAAA KNHPSVAVVV 150
    SPNRYEDVQE ALKTGGFSRA ERTKLAAEAF RHTATYDVTV ATWMSEQLAA 200
    EDSETEFPGW IGTTNTLSRS LRYGENPHQS AALYVGNIRG LAQAKQFHGK 250
    EMSYNNYTDS DAAWRAAWDH ERPCVAIIKH ANPCGIAVSD ESIAAAHREA 300
    HACDSVSAFG GVIASNREVS VEMANQVAEI FTEVIIAPSY EEGAVEILSQ 350
    KKNIRILQAE APVRKGFESR EISGGLLVQE RDLIHAEGDN SANWTLAAGS 400
    AVSPEVLKDL EFAWTAVRSV KSNAILLAKN GATVGVGMGQ VNRVDSARLA 450
    VDRAGAERAT GSVAASDAFF PFADGFEVLA EAGITAVVQP GGSIRDNEVI 500
    EAANKAGVTM YLTGARHFAH 520
    Length:520
    Mass (Da):55,772
    Last modified:May 15, 2007 - v1
    Checksum:i3C7387E84AA1A688
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009044 Genomic DNA. Translation: BAF53951.1.
    RefSeqiYP_001137853.1. NC_009342.1.

    Genome annotation databases

    EnsemblBacteriaiBAF53951; BAF53951; cgR_0976.
    GeneIDi4991704.
    KEGGicgt:cgR_0976.
    PATRICi21506489. VBICorGlu58097_1011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009044 Genomic DNA. Translation: BAF53951.1 .
    RefSeqi YP_001137853.1. NC_009342.1.

    3D structure databases

    ProteinModelPortali A4QCK4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340322.cgR_0976.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF53951 ; BAF53951 ; cgR_0976 .
    GeneIDi 4991704.
    KEGGi cgt:cgR_0976.
    PATRICi 21506489. VBICorGlu58097_1011.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CGLU340322:GJBE-1018-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
      Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
      Microbiology 153:1042-1058(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R.

    Entry informationi

    Entry nameiPUR9_CORGB
    AccessioniPrimary (citable) accession number: A4QCK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3