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A4QCJ4 (G6PI_CORGB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:cgR_0966
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000013961

Sites

Active site3511Proton donor By similarity
Active site3821 By similarity
Active site5061 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QCJ4 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: E69811F6C9082AE5

FASTA54059,150
        10         20         30         40         50         60 
MADISTTQAW QDLTDHYSNF QATTLRELFK EENRAEKYTF SAAGLHVDLS KNLLDDATLT 

        70         80         90        100        110        120 
KLLALTEESG LRERIDAMFA GEHLNNTEDR AVLHTALRLP AEADLSVDGQ DVAADVHEVL 

       130        140        150        160        170        180 
GRMRDFATAL RSGNWLGYTG HTIKKIVNIG IGGSDLGPAM ATKALRAYAT AGISAEFVSN 

       190        200        210        220        230        240 
VDPADLVSVL EDLDAESTLF VVASKTFTTQ ETLSNARAAR AWLVEKLGEE AVAKHFVAVS 

       250        260        270        280        290        300 
TNAEKVAEFG IDTDNMFGFW DWVGGRYSVD SAVGLSLMAV IGPRDFMRFL GGFHAMDEHF 

       310        320        330        340        350        360 
RTTKFEENVP ILMALLGVWY SDFYGAETHA VLPYSEDLSR FAAYLQQLTM ESNGKSVHRD 

       370        380        390        400        410        420 
GSPVSTGTGE IYWGEPGTNG QHAFFQLIHQ GTRLVPADFI GFARPKQDLP AGERTMHDLL 

       430        440        450        460        470        480 
MSNFFAQTKV LAFGKNAEEI AAEGVAPELV NHKVMPGNRP TTTILAEELT PSILGALIAL 

       490        500        510        520        530        540 
YEHIVMVQGV IWDINSFDQW GVELGKQQAN DLAPAVSGEE DVDSGDSSTD SLIKWYRANR

« Hide

References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF53941.1.
RefSeqYP_001137843.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QCJ4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QCJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4992201.
GenomeReviewsGene locus cgR_0966 in contig AP009044_GR.
KEGGcgt:cgR_0966.
PATRIC21506469. VBICorGlu58097_1001.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHBG352954.
OMANSLPAWT.
ProtClustDBPRK00179.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
Gene3DG3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CORGB
AccessionPrimary (citable) accession number: A4QCJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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