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A4QC99 (AROA_CORGB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:cgR_0873
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4304303-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000099693

Sequences

Sequence LengthMass (Da)Tools
A4QC99 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 2D5942E122FEE7D9

FASTA43045,586
        10         20         30         40         50         60 
MVFVSDSSIS LPIWDAPRAR GPIVSDLAIP GSKSITNRAL ILAALASTPS TIIDVLRSRD 

        70         80         90        100        110        120 
TDLMTDGLRS LGITITEEAV DRYRVEPGQL SAGSVECGLA GTVMRFLPPV AAFADGPVHF 

       130        140        150        160        170        180 
DGDPQARVRP MTSILDALRS LGVEVDNNNL PFTVNAGEVP EGGVVEIDAS GSSQFVSGLL 

       190        200        210        220        230        240 
LSAPRFKNGV TVKHVGGRLP SMPHIEMTVD MLRSAGIEIE ESENQWVVHP GEILGRTWRI 

       250        260        270        280        290        300 
EPDLSNATPF LAAAAVTGGT IKINHWPIKT TQPGDAIRSI LERMGCEVEL VAQGEGYDLS 

       310        320        330        340        350        360 
VTGPVALKGI EIDMSDIGEL TPTVAALAAL ASTESRLTGI AHLRGHETDR LAALTAEINK 

       370        380        390        400        410        420 
LGGKCTELKD GLLIEPASLH GGVWHSYADH RMATAGAIIG LAVDDVQVED IKTTSKTFPG 

       430 
FENVWEEMVG

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References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF53846.1.
RefSeqYP_001137748.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QC99.
SMRA4QC99. Positions 13-429.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QC99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4992659.
GenomeReviewsGene locus cgR_0873 in contig AP009044_GR.
KEGGcgt:cgR_0873.
PATRIC21506263. VBICorGlu58097_0905.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0128.
HOGENOMHBG646626.
OMAHRMATAG.
ProtClustDBPRK02427.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_CORGB
AccessionPrimary (citable) accession number: A4QC99
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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