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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Corynebacterium glutamicum (strain R)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:cgR_0668Imported
OrganismiCorynebacterium glutamicum (strain R)Imported
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000006698 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 35HelicalUniRule annotationAdd BLAST19
Transmembranei68 – 95HelicalUniRule annotationAdd BLAST28
Transmembranei116 – 135HelicalUniRule annotationAdd BLAST20
Transmembranei155 – 176HelicalUniRule annotationAdd BLAST22
Transmembranei183 – 202HelicalUniRule annotationAdd BLAST20
Transmembranei214 – 233HelicalUniRule annotationAdd BLAST20
Transmembranei270 – 290HelicalUniRule annotationAdd BLAST21
Transmembranei315 – 334HelicalUniRule annotationAdd BLAST20
Transmembranei374 – 392HelicalUniRule annotationAdd BLAST19
Transmembranei404 – 423HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4QBP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000080586
KOiK03076
OMAiQTYVISQ
OrthoDBiPOG091H024M

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4QBP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIIQAFKD ADLRKKIFFT IAMIVLYRIG AQIPSPGVDY ATISGRLRDL
60 70 80 90 100
TQDQSSVYSL INLFSGGALL QLSIFAIGIM PYITASIIVQ LLTVVIPHFE
110 120 130 140 150
ELKKEGQSGQ AKMMQYTRYL TVALALLQSS GIVALADREQ LLGAGIRVLS
160 170 180 190 200
ADRNFFDLIV LVITMTAGAV LVMWMGELIT EKGVGNGMSL LIFAGIATRL
210 220 230 240 250
PTDGMNILGN SGGVVFAVVL ASVLILVIGV VFVEQGQRRI PVQYAKRMVG
260 270 280 290 300
RRQYGGSSTY LPLKVNQAGV IPVIFASSLI YMPVLITQIV NSGSLEVSDN
310 320 330 340 350
WWQRNIIAHL QTPSSWQYIV LYFALTIFFS YFYVSVQYDP AEQAENMKKY
360 370 380 390 400
GGFIPGIRPG RPTAEYLGFV MNRLLFVGSL YLAVIAVLPN IMLDLGVDAG
410 420 430 440
SAGATPFGGT AILILVSVAL TTVKQIESQL LQSNYEGLLK
Length:440
Mass (Da):47,903
Last modified:May 15, 2007 - v1
Checksum:i3C8871F57A6825E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA Translation: BAF53639.1
RefSeqiWP_003854402.1, NC_009342.1

Genome annotation databases

EnsemblBacteriaiBAF53639; BAF53639; cgR_0668
KEGGicgt:cgR_0668

Similar proteinsi

Entry informationi

Entry nameiA4QBP2_CORGB
AccessioniPrimary (citable) accession number: A4QBP2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health