A4QBG9 (EFG_CORGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	cgR_0597

Organism

Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]

Taxonomic identifier

340322 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 709	709	Elongation factor G HAMAP MF_00054_B		PRO_1000008818
Regions
	Nucleotide binding	19 – 26	8	GTP By similarity
	Nucleotide binding	83 – 87	5	GTP By similarity
	Nucleotide binding	137 – 140	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4QBG9 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 82A4EAD00EB492F4	FASTA	709	77,849
	10 20 30 40 50 60 MAQEVLKDLN KVRNIGIMAH IDAGKTTTTE RILFYTGINR KVGETHDGGA TTDWMEQEKE 70 80 90 100 110 120 RGITITSAAV TCFWDNNQVN IIDTPGHVDF TVEVERSLRV LDGAVAVFDG KEGVEPQSEQ 130 140 150 160 170 180 VWRQATKYDV PRICFVNKMD KLGADFYFTV GTIEDRLGAK PLVMQLPIGA EDNFDGVIDL 190 200 210 220 230 240 LEMKALTWRG VTPIGTEATV EEIPAELADR AAEYREKLLE TVAESDEELM EKYFGGEELS 250 260 270 280 290 300 IAEIKAAIRK MVVNSEIYPV YCGTAYKNKG VQPLLDAVVD FLPSPLDLGE TKGTDVKDPE 310 320 330 340 350 360 KVLTRKPSDE EPLSALAFKI AAHPFFGKLT FVRLYSGKVE PGEQVLNSTK NKKERIGKLF 370 380 390 400 410 420 QMHANKENPV EVAHAGNIYA FIGLKDTTTG DTLCDANAPI ILESMDFPDP VIKVAIEPKT 430 440 450 460 470 480 KSDQEKLGVA IQKLAEEDPT FTVELDDESG QTVIGGMGEL HLDVLVDRMK REFKVEANIG 490 500 510 520 530 540 DPQVAYRETI RKPVESLSYT HKKQTGGSGQ FAKVIITIEP YAPAPEELEE GESAIYKFEN 550 560 570 580 590 600 AVTGGRVPRE YIPSVDAGIQ DAMQYGFLAG YPLVNVKATL EDGAYHDVDS SEMAFKLAGS 610 620 630 640 650 660 QAFKEAVAKA KPVLLEPIMS VEITTPEEYM GEVIGDVNAR RGQIASMDDR AGAKIVKAKV 670 680 690 700 PLSQMFGYVG DLRSKTQGRA NYSMIFDSYA EVPANVAADV IAERNGTAS

References

[1]

"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009044 Genomic DNA. Translation: BAF53566.1.
RefSeq	YP_001137468.1. NC_009342.1.
3D structure databases
ProteinModelPortal	A4QBG9.
SMR	A4QBG9. Positions 1-701.
ModBase	Search...
Protein-protein interaction databases
STRING	A4QBG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4991771.
GenomeReviews	Gene locus cgR_0597 in contig AP009044_GR.
KEGG	cgt:cgR_0597.
PATRIC	21505707. VBICorGlu58097_0628.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HBG737692.
OMA	VAHAGNI.
ProtClustDB	PRK00007.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_CORGB

Accession

Primary (citable) accession number: A4QBG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program