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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

cgR_0526

Organism
Corynebacterium glutamicum (strain R)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (cgR_0526)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciCGLU340322:GJBE-550-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:cgR_0526
OrganismiCorynebacterium glutamicum (strain R)
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000006698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Probable 5-dehydro-4-deoxyglucarate dehydratasePRO_1000045402Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA4QB97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.
OrthoDBiPOG091H00C1.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QB97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFSPQDLA DHLKDGLLSF PATAFQDDLE VDEVAYVEHI EWQSSYPVAG
60 70 80 90 100
LFAAGGTGEG FSLTVEENHR VTQLAVQASS PEVPVLGSAT GSTKSAIANA
110 120 130 140 150
QGAEAAGAEG VLLLPPYLTE CDAEGLYNHA AAVCESTSLG VIVYNRANAI
160 170 180 190 200
YSPEVIARLS ERYPNFIGFK DGTGNIEHLA KITTLCGDRL FYLGGLPTAE
210 220 230 240 250
TFALPLLQMG MSTYSSAMFN FIPDFALSFY ADVRAQDSAA VKQKLSDFVL
260 270 280 290 300
PYLDIRDRAQ GYGVSIVKGG LKAVGRNAGG VRPPLRNLSE QDIADLSDLL
310
ATSGAGSYRL PVEVKA
Length:316
Mass (Da):33,580
Last modified:May 15, 2007 - v1
Checksum:i717B373FDCAA5F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF53494.1.
RefSeqiWP_003855604.1. NC_009342.1.

Genome annotation databases

EnsemblBacteriaiBAF53494; BAF53494; cgR_0526.
KEGGicgt:cgR_0526.
PATRICi21505541. VBICorGlu58097_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF53494.1.
RefSeqiWP_003855604.1. NC_009342.1.

3D structure databases

ProteinModelPortaliA4QB97.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF53494; BAF53494; cgR_0526.
KEGGicgt:cgR_0526.
PATRICi21505541. VBICorGlu58097_0550.

Phylogenomic databases

HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.
OrthoDBiPOG091H00C1.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.
BioCyciCGLU340322:GJBE-550-MONOMER.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDGD_CORGB
AccessioniPrimary (citable) accession number: A4QB97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.