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A4QB76 (DCUP_CORGB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:cgR_0505
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023900

Regions

Region36 – 405Substrate binding By similarity

Sites

Binding site851Substrate By similarity
Binding site1601Substrate By similarity
Binding site2151Substrate By similarity
Binding site3381Substrate By similarity
Site851Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QB76 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 0494FCE80D82AC01

FASTA35838,531
        10         20         30         40         50         60 
MSALTIPAAR RTLNNAPIID AANGKTPTRT PVWFMRQAGR SLPEYKKVRE GISMLDSCFM 

        70         80         90        100        110        120 
PELLAEITLQ PVRRHDVDAA ILFSDIVVPL RAAGVGVEIV AGRGPVLDAP VRSREDVLNL 

       130        140        150        160        170        180 
PILEGNVPEV EQGIGIILDE LSDSQALIGF AGAPFTLASY LVEGGPSKNH EKTKAMMHGD 

       190        200        210        220        230        240 
PETWHALMAR LVPTIVNSLK SQIDAGIDAM QLFDSWAGFL TERDYTEFVL PYSTEILEEV 

       250        260        270        280        290        300 
GKYQLPRIHF GVGTGELLGA MSKAGSEVMG VDWRVPLDKA AERIAAVSGP KVLQGNLDPA 

       310        320        330        340        350 
LLFAGRAPLT KEIERIKAEA QTAIDAGHAT GHIFNLGHGV LPNTVAEDIT EAVSIIHS

« Hide

References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF53473.1.
RefSeqYP_001137375.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QB76.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QB76.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4994297.
GenomeReviewsGene locus cgR_0505 in contig AP009044_GR.
KEGGcgt:cgR_0505.
PATRIC21505499. VBICorGlu58097_0529.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CORGB
AccessionPrimary (citable) accession number: A4QB76
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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