Reviewed,
UniProtKB/Swiss-Prot A4QB65 (AROE_CORGB)
Last modified
November 3, 2009.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Quinate/shikimate dehydrogenase EC=1.1.1.24 EC=1.1.1.- Alternative name(s): NAD(+)-dependent quinate dehydrogenase Short name=QDH | ||||
| Gene names |
| ||||
| Organism | Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 340322 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium |
Protein attributes
| Sequence length | 283 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NAD+-dependent oxidation of both quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate, respectively. Seems to play a key role in the quinate degradation pathway By similarity. |
| Catalytic activity | Quinate + NAD+ = 3-dehydroquinate + NADH. HAMAP MF_00222 Shikimate + NAD+ = 3-dehydroshikimate + NADH. HAMAP MF_00222 |
| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the shikimate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro quinate 5-dehydrogenase activityInferred from electronic annotation. Source: EC shikimate 5-dehydrogenase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 283 | 283 | Quinate/shikimate dehydrogenase HAMAP MF_00222 | PRO_0000351451 | |||||
Regions | |||||||||
| Nucleotide binding | 134 – 138 | 5 | NAD By similarity | ||||||
| Nucleotide binding | 251 – 255 | 5 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 73 | 1 | Proton acceptor Potential | ||||||
| Binding site | 110 | 1 | Substrate By similarity | ||||||
| Binding site | 158 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AP009044 Genomic DNA. Translation: BAF53462.1. | |
| RefSeq | YP_001137364.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A4QB65. |
Genome annotation databases | |
| GeneID | 4994338. |
| GenomeReviews | Gene locus cgR_0495 in contig AP009044_GR. |
| KEGG | cgt:cgR_0495. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | VKAFELF. |
Family and domain databases | |
| HAMAP | MF_00222. Divergent sequence. [Tree] |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AROE_CORGB | ||||||||
| Accession | Primary (citable) accession number: A4QB65 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


