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Protein

Dihydrolipoyl dehydrogenase

Gene

cgR_0439

Organism
Corynebacterium glutamicum (strain R)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:cgR_0439Imported
OrganismiCorynebacterium glutamicum (strain R)Imported
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000006698 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliA4QB06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 327FAD/NAD-binding_domInterPro annotationAdd BLAST323
Domaini348 – 459Pyr_redox_dimInterPro annotationAdd BLAST112

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiCSDGMTK.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QB06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEHYDVVVL GAGPGGYVSA IRAAQLGKKV AVIEKQYWGG ICLNVGCIPS
60 70 80 90 100
KSLIKNAEVA HTFTHEKKTF GINGEVTFNY EDAHKRSRGV SDKIVGGVHY
110 120 130 140 150
LMKKNKITEI HGLGNFKDAK TIEVTDGKDA GKTVTFDDCI IATGSVVNTL
160 170 180 190 200
RGVEFSKNVV SFEEQILDPV APKKMVIVGA GAIGMEFAYV LGNYGVDVTV
210 220 230 240 250
IEFMDRVLPN EDAEVSKVIA KAYKKMGVKL LPGHATTAVR DNGDSVEVDY
260 270 280 290 300
QKKGSDKTET LTVDRVMVSV GFRPRVEGFG LENTGVKLTE RGAIDIDDYM
310 320 330 340 350
RTNVPGIYAI GDVTAKLQLA HVAEAQGIVA AETIAGAETQ ALGDYMMMPR
360 370 380 390 400
ATFCNPQVAS FGYTEEQAKQ KWPDREIKVA SFPFSANGKA VGLAETDGFA
410 420 430 440 450
KIVADAEFGE LLGGHLVGAN ASELINELVL AQNWDLTTEE ISRSVHIHPT
460
LSEAVKEAAH GISGHMINF
Length:469
Mass (Da):50,501
Last modified:May 15, 2007 - v1
Checksum:i384E1E4DBD71F33F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF53403.1.
RefSeqiWP_011896653.1. NC_009342.1.

Genome annotation databases

EnsemblBacteriaiBAF53403; BAF53403; cgR_0439.
KEGGicgt:cgR_0439.
PATRICi21505359. VBICorGlu58097_0459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF53403.1.
RefSeqiWP_011896653.1. NC_009342.1.

3D structure databases

ProteinModelPortaliA4QB06.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF53403; BAF53403; cgR_0439.
KEGGicgt:cgR_0439.
PATRICi21505359. VBICorGlu58097_0459.

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiCSDGMTK.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4QB06_CORGB
AccessioniPrimary (citable) accession number: A4QB06
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.