A4QAF9 (IOLG_CORGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	cgR_0243

Organism

Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]

Taxonomic identifier

340322 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352567

Sequences

	Sequence		Length	Mass (Da)
	A4QAF9 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 94A1F7B046AB1319	FASTA	337	36,491
	10 20 30 40 50 60 MSKSLRVGVV GAGAMGADHI DRINNRTSGA HISAIIEPDA ARAAAAAENA PGAQAFTRIE 70 80 90 100 110 120 DAIAADAVDA VLIAVPGQFH EPVLVPALEA GLPILCEKPL TPDSESSLRI VELEQKLDKP 130 140 150 160 170 180 HIQVGFMRRF DPEYNNLRKL VESGEAGELL MLRGLHRNPS VGENYTQSML ITDSVVHEFD 190 200 210 220 230 240 VIPWLAGSRV VSVEVKYPKT SSLAHSGLKE PILVIMELEN GVLVDVEMNV NIQFGYQVAT 250 260 270 280 290 300 EAVFEKGLAR IGQPSGMQRW RDGEFLINEH TDFTTRFATA YDRQIQSWVD AVHEGTLVAG 310 320 330 PNAWDGYLVA LSCEAGVKAF DGGVIPVDAA PRPDFYA

References

[1]

"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009044 Genomic DNA. Translation: BAF53206.1.
RefSeq	YP_001137108.1. NC_009342.1.
3D structure databases
ProteinModelPortal	A4QAF9.
ModBase	Search...
Protein-protein interaction databases
STRING	A4QAF9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4992142.
GenomeReviews	Gene locus cgR_0243 in contig AP009044_GR.
KEGG	cgt:cgR_0243.
PATRIC	21504932. VBICorGlu58097_0254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	RTEVVGE.
ProtClustDB	CLSK632711.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_CORGB

Accession

Primary (citable) accession number: A4QAF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program