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Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Corynebacterium glutamicum (strain R)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCGLU340322:GJBE-254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:cgR_0243
OrganismiCorynebacterium glutamicum (strain R)
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000006698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Inositol 2-dehydrogenasePRO_0000352567Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4QAF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiTAEGCKR.
OrthoDBiEOG6GFGMS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

A4QAF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSLRVGVV GAGAMGADHI DRINNRTSGA HISAIIEPDA ARAAAAAENA
60 70 80 90 100
PGAQAFTRIE DAIAADAVDA VLIAVPGQFH EPVLVPALEA GLPILCEKPL
110 120 130 140 150
TPDSESSLRI VELEQKLDKP HIQVGFMRRF DPEYNNLRKL VESGEAGELL
160 170 180 190 200
MLRGLHRNPS VGENYTQSML ITDSVVHEFD VIPWLAGSRV VSVEVKYPKT
210 220 230 240 250
SSLAHSGLKE PILVIMELEN GVLVDVEMNV NIQFGYQVAT EAVFEKGLAR
260 270 280 290 300
IGQPSGMQRW RDGEFLINEH TDFTTRFATA YDRQIQSWVD AVHEGTLVAG
310 320 330
PNAWDGYLVA LSCEAGVKAF DGGVIPVDAA PRPDFYA
Length:337
Mass (Da):36,491
Last modified:May 15, 2007 - v1
Checksum:i94A1F7B046AB1319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF53206.1.
RefSeqiWP_011896510.1. NC_009342.1.

Genome annotation databases

EnsemblBacteriaiBAF53206; BAF53206; cgR_0243.
KEGGicgt:cgR_0243.
PATRICi21504932. VBICorGlu58097_0254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA. Translation: BAF53206.1.
RefSeqiWP_011896510.1. NC_009342.1.

3D structure databases

ProteinModelPortaliA4QAF9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF53206; BAF53206; cgR_0243.
KEGGicgt:cgR_0243.
PATRICi21504932. VBICorGlu58097_0254.

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiTAEGCKR.
OrthoDBiEOG6GFGMS.

Enzyme and pathway databases

BioCyciCGLU340322:GJBE-254-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
    Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
    Microbiology 153:1042-1058(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R.

Entry informationi

Entry nameiIOLG_CORGB
AccessioniPrimary (citable) accession number: A4QAF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: May 15, 2007
Last modified: December 9, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.