A4Q9R9 (DNAA_CORGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	cgR_0001

Organism

Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]

Taxonomic identifier

340322 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000048640
Regions
	Nucleotide binding	224 – 231	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A4Q9R9 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 716511FE95B05BEC	FASTA	524	58,436
	10 20 30 40 50 60 MSQNSSSLLE TWRQVVADLT TLSQQADSGF DPLTPTQRAY LNLTKPIAIV DGYAVLSTPN 70 80 90 100 110 120 AMAKNVIEND LGDALTRVLS LRMGRSFSLA VSVEPEQEIP ETPAQQEFKY QPDAPVISSN 130 140 150 160 170 180 KAPKQYEVGG RGGASTSDGW ERTHSAPAPE PHPAPIADPE PELATPQRIP RETPAHNPNR 190 200 210 220 230 240 EVSLNPKYTF ESFVIGPFNR FANAAAVAVA ESPAKAFNPL FISGGSGLGK THLLHAVGNY 250 260 270 280 290 300 AQELQPGLRI KYVSSEEFTN DYINSVRDDR QETFKRRYRN LDILMVDDIQ FLAGKEGTQE 310 320 330 340 350 360 EFFHTFNALH QADKQIILSS DRPPKQLTTL EDRLRTRFEG GLITDIQPPD LETRIAILMK 370 380 390 400 410 420 KAQTDGTHVD REVLELIASR FESSIRELEG ALIRVSAYSS LINQPIDKEM AIVALRDILP 430 440 450 460 470 480 EPEDMEITAP VIMEVTAEYF EISVDTLRGA GKTRAVAHAR QLAMYLCREL TDMSLPKIGD 490 500 510 520 VFGGKDHTTV MYADRKIRQE MTEKRDTYDE IQQLTQLIKS RGRN

References

[1]

"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009044 Genomic DNA. Translation: BAF52962.1.
RefSeq	YP_001136864.1. NC_009342.1.
3D structure databases
ProteinModelPortal	A4Q9R9.
ModBase	Search...
Protein-protein interaction databases
STRING	A4Q9R9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4992463.
GenomeReviews	Gene locus cgR_0001 in contig AP009044_GR.
KEGG	cgt:cgR_0001.
PATRIC	21504412. VBICorGlu58097_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	DEVAFLI.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_CORGB

Accession

Primary (citable) accession number: A4Q9R9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program