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A4Q8G1

- GH109_TANFO

UniProt

A4Q8G1 - GH109_TANFO

Protein

Alpha-N-acetylgalactosaminidase

Gene

nagA

Organism
Tannerella forsythia (Bacteroides forsythus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Glycosidase that has specific alpha-N-acetylgalactosaminidase activity.

    Catalytic activityi

    Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.1 Publication

    Cofactori

    Binds 1 NAD+ per subunit. The NAD cannot dissociate By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841NADBy similarity
    Binding sitei183 – 1831NADBy similarity
    Binding sitei212 – 2121SubstrateBy similarity
    Binding sitei248 – 2481SubstrateBy similarity
    Binding sitei260 – 2601NADBy similarity
    Binding sitei342 – 3421SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi62 – 632NADBy similarity
    Nucleotide bindingi133 – 1364NADBy similarity
    Nucleotide bindingi154 – 1552NADBy similarity
    Nucleotide bindingi243 – 2475NADBy similarity

    GO - Molecular functioni

    1. alpha-N-acetylgalactosaminidase activity Source: UniProtKB-EC
    2. oxidoreductase activity Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    NAD

    Protein family/group databases

    CAZyiGH109. Glycoside Hydrolase Family 109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-N-acetylgalactosaminidase (EC:3.2.1.49)
    Alternative name(s):
    Glycosyl hydrolase family 109 protein
    Gene namesi
    Name:nagA
    OrganismiTannerella forsythia (Bacteroides forsythus)
    Taxonomic identifieri28112 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeTannerella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Chaini31 – 468438Alpha-N-acetylgalactosaminidasePRO_0000348548Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Structurei

    3D structure databases

    ProteinModelPortaliA4Q8G1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni260 – 2634Substrate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    IPR006311. TAT_signal.
    IPR019546. TAT_signal_bac_arc.
    [Graphical view]
    PfamiPF01408. GFO_IDH_MocA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
    PROSITEiPS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4Q8G1-1 [UniParc]FASTAAdd to Basket

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    MENTRRNFLK KVTAAGIGAA GLAVTDQAMA AVNQPGEAAQ QKKKPAGKSD    50
    GMLRFGFIGT GSRCQEHINN VLGIQGNKIV AICDIQKGPL EKTLKHIAKF 100
    NVPEPKVYTG GEREFEKMLN NEEFDCVIIA SPWEWHVPMA VAAMKAGVPY 150
    VGVEVSAANT VEECWDLVNV SEATGSHLNI LENVCYRRDV MAALRMVREG 200
    LFGEMIHGTC GYQHDLRDVK FNDGIHYTYQ EGGELRMGPT AYAEAQWRTQ 250
    HSVTRNGDIY PTHGIGPVAN CLNINRGNRF LSLTSMATQS RGLHNFVVDK 300
    GGANHPYAKI HFNLGDIVTS MIKCANGQTV IVTHDTNLPR PYSLGFRIQG 350
    TRGLWMNDGN HVYVEGQSKP HRWDASDDWF KKYDHKLWST LELKAKEAGH 400
    GGMDYIMMYD FIDAIRNKKP TPMDCYDAAA WSAISGLSEM SIARGGAVVD 450
    FPDFTRGQWI HRQPAFAL 468
    Length:468
    Mass (Da):51,923
    Last modified:May 15, 2007 - v1
    Checksum:i582356F5CE376FE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM039448 Genomic DNA. Translation: CAJ01380.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM039448 Genomic DNA. Translation: CAJ01380.1 .

    3D structure databases

    ProteinModelPortali A4Q8G1.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH109. Glycoside Hydrolase Family 109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    IPR006311. TAT_signal.
    IPR019546. TAT_signal_bac_arc.
    [Graphical view ]
    Pfami PF01408. GFO_IDH_MocA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01409. TAT_signal_seq. 1 hit.
    PROSITEi PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYME ACTIVITY.
      Strain: ATCC 43037 / JCM 10827 / FDC 338 / CIP 105219.

    Entry informationi

    Entry nameiGH109_TANFO
    AccessioniPrimary (citable) accession number: A4Q8G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3