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A4Q8G1

- GH109_TANFO

UniProt

A4Q8G1 - GH109_TANFO

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Protein

Alpha-N-acetylgalactosaminidase

Gene

nagA

Organism
Tannerella forsythia (Bacteroides forsythus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glycosidase that has specific alpha-N-acetylgalactosaminidase activity.

Catalytic activityi

Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.1 Publication

Cofactori

Binds 1 NAD+ per subunit. The NAD cannot dissociate (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841NADBy similarity
Binding sitei183 – 1831NADBy similarity
Binding sitei212 – 2121SubstrateBy similarity
Binding sitei248 – 2481SubstrateBy similarity
Binding sitei260 – 2601NADBy similarity
Binding sitei342 – 3421SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632NADBy similarity
Nucleotide bindingi133 – 1364NADBy similarity
Nucleotide bindingi154 – 1552NADBy similarity
Nucleotide bindingi243 – 2475NADBy similarity

GO - Molecular functioni

  1. alpha-N-acetylgalactosaminidase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

NAD

Protein family/group databases

CAZyiGH109. Glycoside Hydrolase Family 109.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminidase (EC:3.2.1.49)
Alternative name(s):
Glycosyl hydrolase family 109 protein
Gene namesi
Name:nagA
OrganismiTannerella forsythia (Bacteroides forsythus)
Taxonomic identifieri28112 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeTannerella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Tat-type signalPROSITE-ProRule annotationAdd
BLAST
Chaini31 – 468438Alpha-N-acetylgalactosaminidasePRO_0000348548Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Structurei

3D structure databases

ProteinModelPortaliA4Q8G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni260 – 2634Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4Q8G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENTRRNFLK KVTAAGIGAA GLAVTDQAMA AVNQPGEAAQ QKKKPAGKSD
60 70 80 90 100
GMLRFGFIGT GSRCQEHINN VLGIQGNKIV AICDIQKGPL EKTLKHIAKF
110 120 130 140 150
NVPEPKVYTG GEREFEKMLN NEEFDCVIIA SPWEWHVPMA VAAMKAGVPY
160 170 180 190 200
VGVEVSAANT VEECWDLVNV SEATGSHLNI LENVCYRRDV MAALRMVREG
210 220 230 240 250
LFGEMIHGTC GYQHDLRDVK FNDGIHYTYQ EGGELRMGPT AYAEAQWRTQ
260 270 280 290 300
HSVTRNGDIY PTHGIGPVAN CLNINRGNRF LSLTSMATQS RGLHNFVVDK
310 320 330 340 350
GGANHPYAKI HFNLGDIVTS MIKCANGQTV IVTHDTNLPR PYSLGFRIQG
360 370 380 390 400
TRGLWMNDGN HVYVEGQSKP HRWDASDDWF KKYDHKLWST LELKAKEAGH
410 420 430 440 450
GGMDYIMMYD FIDAIRNKKP TPMDCYDAAA WSAISGLSEM SIARGGAVVD
460
FPDFTRGQWI HRQPAFAL
Length:468
Mass (Da):51,923
Last modified:May 15, 2007 - v1
Checksum:i582356F5CE376FE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039448 Genomic DNA. Translation: CAJ01380.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039448 Genomic DNA. Translation: CAJ01380.1 .

3D structure databases

ProteinModelPortali A4Q8G1.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH109. Glycoside Hydrolase Family 109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view ]
Pfami PF01408. GFO_IDH_MocA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01409. TAT_signal_seq. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYME ACTIVITY.
    Strain: ATCC 43037 / JCM 10827 / FDC 338 / CIP 105219.

Entry informationi

Entry nameiGH109_TANFO
AccessioniPrimary (citable) accession number: A4Q8G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 15, 2007
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3