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A4Q8G1

- GH109_TANFO

UniProt

A4Q8G1 - GH109_TANFO

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Protein

Alpha-N-acetylgalactosaminidase

Gene
nagA
Organism
Tannerella forsythia (Bacteroides forsythus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycosidase that has specific alpha-N-acetylgalactosaminidase activity.

Catalytic activityi

Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.1 Publication

Cofactori

Binds 1 NAD+ per subunit. The NAD cannot dissociate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841NAD By similarity
Binding sitei183 – 1831NAD By similarity
Binding sitei212 – 2121Substrate By similarity
Binding sitei248 – 2481Substrate By similarity
Binding sitei260 – 2601NAD By similarity
Binding sitei342 – 3421Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632NAD By similarity
Nucleotide bindingi133 – 1364NAD By similarity
Nucleotide bindingi154 – 1552NAD By similarity
Nucleotide bindingi243 – 2475NAD By similarity

GO - Molecular functioni

  1. alpha-N-acetylgalactosaminidase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

NAD

Protein family/group databases

CAZyiGH109. Glycoside Hydrolase Family 109.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminidase (EC:3.2.1.49)
Alternative name(s):
Glycosyl hydrolase family 109 protein
Gene namesi
Name:nagA
OrganismiTannerella forsythia (Bacteroides forsythus)
Taxonomic identifieri28112 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeTannerella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Tat-type signal Reviewed predictionAdd
BLAST
Chaini31 – 468438Alpha-N-acetylgalactosaminidasePRO_0000348548Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Structurei

3D structure databases

ProteinModelPortaliA4Q8G1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni260 – 2634Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4Q8G1-1 [UniParc]FASTAAdd to Basket

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MENTRRNFLK KVTAAGIGAA GLAVTDQAMA AVNQPGEAAQ QKKKPAGKSD    50
GMLRFGFIGT GSRCQEHINN VLGIQGNKIV AICDIQKGPL EKTLKHIAKF 100
NVPEPKVYTG GEREFEKMLN NEEFDCVIIA SPWEWHVPMA VAAMKAGVPY 150
VGVEVSAANT VEECWDLVNV SEATGSHLNI LENVCYRRDV MAALRMVREG 200
LFGEMIHGTC GYQHDLRDVK FNDGIHYTYQ EGGELRMGPT AYAEAQWRTQ 250
HSVTRNGDIY PTHGIGPVAN CLNINRGNRF LSLTSMATQS RGLHNFVVDK 300
GGANHPYAKI HFNLGDIVTS MIKCANGQTV IVTHDTNLPR PYSLGFRIQG 350
TRGLWMNDGN HVYVEGQSKP HRWDASDDWF KKYDHKLWST LELKAKEAGH 400
GGMDYIMMYD FIDAIRNKKP TPMDCYDAAA WSAISGLSEM SIARGGAVVD 450
FPDFTRGQWI HRQPAFAL 468
Length:468
Mass (Da):51,923
Last modified:May 15, 2007 - v1
Checksum:i582356F5CE376FE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039448 Genomic DNA. Translation: CAJ01380.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039448 Genomic DNA. Translation: CAJ01380.1 .

3D structure databases

ProteinModelPortali A4Q8G1.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH109. Glycoside Hydrolase Family 109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view ]
Pfami PF01408. GFO_IDH_MocA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01409. TAT_signal_seq. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYME ACTIVITY.
    Strain: ATCC 43037 / JCM 10827 / FDC 338 / CIP 105219.

Entry informationi

Entry nameiGH109_TANFO
AccessioniPrimary (citable) accession number: A4Q8G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 15, 2007
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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