Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Na(+)-translocating NADH-quinone reductase subunit F

Gene

nqrF

Organism
Haemophilus influenzae R3021
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.UniRule annotation

Catalytic activityi

NADH + ubiquinone + n Na+(In) = NAD+ + ubiquinol + n Na+(Out).UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotation
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi73Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi79Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi82Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi114Iron-sulfur (2Fe-2S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processIon transport, Sodium transportUniRule annotation, Transport
Ligand2Fe-2SUniRule annotationSAAS annotation, FADUniRule annotation, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NADUniRule annotation, Sodium, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit FUniRule annotation (EC:1.6.5.8UniRule annotation)
Short name:
Na(+)-NQR subunit FUniRule annotation
Short name:
Na(+)-translocating NQR subunit FUniRule annotation
Alternative name(s):
NQR complex subunit FUniRule annotation
NQR-1 subunit FUniRule annotation
Gene namesi
Name:nqrFUniRule annotation
ORF Names:CGSHi22421_01182Imported
OrganismiHaemophilus influenzae R3021Imported
Taxonomic identifieri375432 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000003798 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 28HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4N576
SMRiA4N576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 1302Fe-2S ferredoxin-typeInterPro annotationAdd BLAST95
Domaini133 – 273FAD-binding FR-typeInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the NqrF family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OrthoDBiPOG091H05VQ

Family and domain databases

Gene3Di3.10.20.30, 1 hit
HAMAPiMF_00430 NqrF, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR012675 Beta-grasp_dom_sf
IPR017927 Fd_Rdtase_FAD-bd
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR010205 NqrF
IPR008333 OxRdtase_FAD-bd_dom
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00970 FAD_binding_6, 1 hit
PF00111 Fer2, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000044 Cis_Diol_DH_RD, 1 hit
PRINTSiPR00371 FPNCR
SUPFAMiSSF54292 SSF54292, 1 hit
SSF63380 SSF63380, 1 hit
TIGRFAMsiTIGR01941 nqrF, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

A4N576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSVILALG IAAFTVIVLV LVAIILFAKS KLVDSGDITI DINDDPEKAI
60 70 80 90 100
TLPAGGKLLG ALASKGIFVS SACGGGGSCG QCIVKVKNGG GEILPTELSH
110 120 130 140 150
INKREAKEGY RLACQVNVKG NMEVELPEEI FGVKKWECTV ISNDNKATFI
160 170 180 190 200
KELKLAIPEG EEVPFRAGGY IQIEAEPHVV NYKDFDIPEE YHEDWDKYDL
210 220 230 240 250
WRYVSKVDEH IIRAYSMASY PEEKGIIMLN VRIATPPPRQ PDAPPGQMSS
260 270 280 290 300
YIWSLKAGDK VTISGPFGEF FAKETDAEMV FIGGGAGMAP MRSHIFDQLK
310 320 330 340 350
RLHSKRKMSF WYGARSKREI FYQEDFDQLQ AENPNFVWHV ALSDALPEDN
360 370 380 390 400
WTGYTGFIHN VLYENYLKNH EAPEDCEYYM CGPPVMNAAV IKMLKDLGVE
410
DENILLDDFG G
Length:411
Mass (Da):45,705
Last modified:May 15, 2007 - v1
Checksum:iED560053E66D23E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZE01000011 Genomic DNA Translation: EDJ90575.1

Genome annotation databases

EnsemblBacteriaiEDJ90575; EDJ90575; CGSHi22421_01182

Similar proteinsi

Entry informationi

Entry nameiA4N576_HAEIF
AccessioniPrimary (citable) accession number: A4N576
Entry historyiIntegrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health