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Protein
Submitted name:

Histone-lysine N-methyltransferase

Gene

met-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • histone H3-K36 methylation Source: WormBase
  • histone H3-K9 methylation Source: WormBase
  • negative regulation of transcription by RNA polymerase II Source: WormBase
  • negative regulation of vulval development Source: WormBase

Keywordsi

Molecular functionMethyltransferaseSAAS annotationImported, Transferase
LigandS-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferaseImported
Gene namesi
Name:met-1Imported
ORF Names:C43E11.3Imported, CELE_C43E11.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC43E11.3a ; CE30503 ; WBGene00016603 ; met-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

EPDiA4LBC2
PaxDbiA4LBC2
PeptideAtlasiA4LBC2

PTM databases

iPTMnetiA4LBC2

Expressioni

Gene expression databases

BgeeiWBGene00016603
ExpressionAtlasiA4LBC2 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.C43E11.3a

Structurei

3D structure databases

ProteinModelPortaliA4LBC2
SMRiA4LBC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini636 – 681AWSInterPro annotationAdd BLAST46
Domaini683 – 805SETInterPro annotationAdd BLAST123
Domaini812 – 828Post-SETInterPro annotationAdd BLAST17
Domaini1366 – 1393WWInterPro annotationAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili485 – 505Sequence analysisAdd BLAST21
Coiled coili561 – 614Sequence analysisAdd BLAST54
Coiled coili1319 – 1361Sequence analysisAdd BLAST43

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOGENOMiHOG000263480
InParanoidiA4LBC2
OMAiTWLIKLI
OrthoDBiEOG091G040P

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4LBC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQRKVVLPK KRTEMVQTRR KTAAAVQDGG AVKENKAKPP APQTPTKRAK
60 70 80 90 100
RGRPPKIKTD ANTLNTPSTS SNLVDDKLLI ESESQDSILT NEADSFLEKE
110 120 130 140 150
VEEIEDSSDI LPDKINSPEK PSVLVKRRSS TRLKVKTDED EKDVPVNIEV
160 170 180 190 200
AVLEEKSIQI EPTSPAHPED PQPSTSSLPL VEPIEDIVEP NEPTSSADPP
210 220 230 240 250
VSNIKDEDIK EEEPLIKKPA SDESESMDIA NSESGNDSDS SEADPRTIPS
260 270 280 290 300
FSIPLPDTPP PNFAKRGEIH VDVDQKNSKQ SGESQSPWER AREKSASNPL
310 320 330 340 350
SSPTMSRPRI HFLHPAYQSF TNDSVSPLPP PPPEPAPARE KVENGGPTTF
360 370 380 390 400
KMTFKKAANI PILKTSAFEQ PSSPPPSSSV SSSISLSEVN SSTSIASESS
410 420 430 440 450
PAKRSSNFDL TASNELPPPQ MVELPKLSFF NMPPAVRSAE DDSAMTSEEP
460 470 480 490 500
ILLLRSPNSA TPDDDALFLT TPPPPKMTES EIQALKVATE KVNQVIARRE
510 520 530 540 550
DSEKDVRHRE DRDDYDRRRD DRDRRSRKTD SERNDQRGRQ REDDERRARE
560 570 580 590 600
REREVTKRHD REREEMRLQK QKDEERRKKD EEERIQKEND EKKQKEDEAK
610 620 630 640 650
MEEEKKKIKE EEMKIPEFEL ISESKYLTRN ANKKKTESLT CECHRTGGNC
660 670 680 690 700
SDNTCVNRAM LTECPSSCQV KCKNQRFAKK KYAAVEAFHT GTAKGCGLRA
710 720 730 740 750
VKDIKKGRFI IEYIGEVVER DDYEKRKTKY AADKKHKHHY LCDTGVYTID
760 770 780 790 800
ATVYGNPSRF VNHSCDPNAI CEKWSVPRTP GDVNRVGFFS KRFIKAGEEI
810 820 830 840 850
TFDYQFVNYG RDAQQCFCGS ASCSGWIGQK PEEFSSDEDD DIVTTRHINM
860 870 880 890 900
DEEEEEKLEG LDHLGNHERN EVIKDMLDDL VIRNKKHARK VITIASAMTD
910 920 930 940 950
YSQRVDVIQE IFSSDTSVTV QKFYAKEGMA TLMAEWLSED DYSLDNLKLV
960 970 980 990 1000
QAILKALHTE LFDSCAKNDR LLRDSTSRWV NAKMDEYVDI QVIADSLIAC
1010 1020 1030 1040 1050
VEDPVQEYKD VCKVIEKGLV ENFTRAKEMA YRLNQYWFNR SVSFKIPKKI
1060 1070 1080 1090 1100
RDPVPKDVPV RQEDATTSSQ SHDNSSRTVS PNHRHHSSSY SNSCYQEREP
1110 1120 1130 1140 1150
SHIRFFNNGN DVHQYRFGGY HGNNYNDNYF SRRPNKDSYR DRRRFNGRRS
1160 1170 1180 1190 1200
RSRSRSVSPQ NYKRRKLDEH DNNHRQRSPI RDRHTSPGGE KTPSSNNSGE
1210 1220 1230 1240 1250
RNYKRLDIRG ARIKTIKEDL EAAAAAAAAA AVPSEVQAYP HEHTAVHQSV
1260 1270 1280 1290 1300
YQMPGYESYG VYDPVNGVYM YPHPGAGYYP PAYPQQPIML TMDTLPPNDR
1310 1320 1330 1340 1350
LGELYEKASI EQLAQRDAIV RQELELIRIQ IERKTAQKEA IKAACRRANE
1360 1370 1380 1390 1400
EEAKRQEALA KTKYVWAIAK SEAGETYYYN KITKETQWTA PTPVQGLLEP
1410 1420 1430 1440 1450
ACGASPDTTV VIADEITEEE QQAEVLEKPR VVKEEVIEPG SQSETQKESP
1460 1470 1480 1490 1500
EKVRVVVPKV EVERSPSPKS SRDREKDREK SREKDRERDR DRREGSKHRD
1510 1520 1530 1540 1550
SYHGHRNGSS SVSERRMREF KHELERSTRS AVRSRLQHQR DASSDKTTWL
1560 1570 1580 1590 1600
IKLIYREIFK RESAQSGFDY RFSENTDKKV KNYVKSYIDR KLESNDLWKE

YSRP
Length:1,604
Mass (Da):183,463
Last modified:May 1, 2007 - v1
Checksum:i3F4AAB1CF9217FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD65166.1
RefSeqiNP_491340.2, NM_058939.4
UniGeneiCel.4961

Genome annotation databases

EnsemblMetazoaiC43E11.3a; C43E11.3a; WBGene00016603
GeneIDi172026
KEGGicel:CELE_C43E11.3
UCSCiC43E11.3a c. elegans

Similar proteinsi

Entry informationi

Entry nameiA4LBC2_CAEEL
AccessioniPrimary (citable) accession number: A4LBC2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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