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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

Pds5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2468052. Establishment of Sister Chromatid Cohesion.
R-RNO-2470946. Cohesin Loading onto Chromatin.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
Gene namesi
Name:Pds5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1307094. Pds5a.

Subcellular locationi

  • Nucleus By similarity

  • Note: Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333Sister chromatid cohesion protein PDS5 homolog APRO_0000296343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei1145 – 11451N6-acetyllysineBy similarity
Modified residuei1174 – 11741PhosphoserineCombined sources
Modified residuei1194 – 11941PhosphoserineBy similarity
Modified residuei1207 – 12071PhosphothreonineBy similarity
Modified residuei1210 – 12101N6-acetyllysineBy similarity
Modified residuei1289 – 12891N6-acetyllysineBy similarity
Modified residuei1304 – 13041PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA4L9P7.
PRIDEiA4L9P7.

PTM databases

iPTMnetiA4L9P7.
PhosphoSiteiA4L9P7.

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003437.

Structurei

3D structure databases

ProteinModelPortaliA4L9P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati392 – 42837HEATSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the PDS5 family.Curated
Contains 1 HEAT repeat.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1525. Eukaryota.
ENOG410XQW7. LUCA.
GeneTreeiENSGT00390000012488.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiA4L9P7.
KOiK11267.
OMAiTCFDIVS.
OrthoDBiEOG73Z2SD.
PhylomeDBiA4L9P7.
TreeFamiTF106415.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

A4L9P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT
60 70 80 90 100
FMDMDQDSED EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY
110 120 130 140 150
APEAPYTSHD KLKDIFLFIT RQLKGLEDTK SPQFNRYFYL LENLAWVKSY
160 170 180 190 200
NICFELEDCN EIFIQLFRTL FSVINNSHNK KVQMHMLDLM SSIIMEGDGV
210 220 230 240 250
TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA CIANFFNQVL
260 270 280 290 300
VLGRSSVSDL SEHVFDLIQE LFAIDPHLLL SVMPQLEFKL KSNDGEERLA
310 320 330 340 350
VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL
360 370 380 390 400
MNHPDLAKDL TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG
410 420 430 440 450
FVRERTLDKR WRVRKEAMMG LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL
460 470 480 490 500
HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE ERMKCLYYLY ASLDPNAVKA
510 520 530 540 550
LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT IAKNLPDPGK
560 570 580 590 600
AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADICVR EIARKLANPK
610 620 630 640 650
QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS
660 670 680 690 700
PDSAIRSGLE LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI
710 720 730 740 750
FRNTGHKIET DLPQIRSTLI PILHQKAKRG TPHQAKQAVH CIHAIFSNKE
760 770 780 790 800
VQLAQIFEPL SRSLNADVPE QLITPLVSLG HISMLAPDQF ASPMKSVVAN
810 820 830 840 850
FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVQAIKL LVRWLLGMKN
860 870 880 890 900
NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ
910 920 930 940 950
EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA
960 970 980 990 1000
IFALCAKDPV KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV
1010 1020 1030 1040 1050
VPYMIHLLAH DPDFTRSQDV DQLRDIKECL WFMLEVLMTK NENNSHAFMK
1060 1070 1080 1090 1100
KMAENIKLTR DAQSPDEAKT NEKLYTVCDV ALCVINSKSA LCNADSPKDP
1110 1120 1130 1140 1150
VLPMKFFTQP EKDFSNDKSY ISEETRVLLL TGKPKPTGVL GTVNKPLSAT
1160 1170 1180 1190 1200
GRKPYVRSAG TETGSNINAS SELSPSAGNR SREQSSEASE TGVSENEENP
1210 1220 1230 1240 1250
VRIISVTPVK SIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQQ
1260 1270 1280 1290 1300
KPDEKADESG PPAPSKPRRG RRPKSESQGN ATKNDDLSKP VSKGRKRAAG
1310 1320 1330
SQESLEAGNA KAPKLQDGAK KAVPAERQID LQR
Length:1,333
Mass (Da):150,286
Last modified:May 1, 2007 - v1
Checksum:iAC6FC6215E0F7F56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF460313 mRNA. Translation: ABO47655.1.
RefSeqiNP_001077093.1. NM_001083624.1.
UniGeneiRn.224580.
Rn.24482.

Genome annotation databases

EnsembliENSRNOT00000003437; ENSRNOP00000003437; ENSRNOG00000002541.
GeneIDi305343.
KEGGirno:305343.
UCSCiRGD:1307094. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF460313 mRNA. Translation: ABO47655.1.
RefSeqiNP_001077093.1. NM_001083624.1.
UniGeneiRn.224580.
Rn.24482.

3D structure databases

ProteinModelPortaliA4L9P7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003437.

PTM databases

iPTMnetiA4L9P7.
PhosphoSiteiA4L9P7.

Proteomic databases

PaxDbiA4L9P7.
PRIDEiA4L9P7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003437; ENSRNOP00000003437; ENSRNOG00000002541.
GeneIDi305343.
KEGGirno:305343.
UCSCiRGD:1307094. rat.

Organism-specific databases

CTDi23244.
RGDi1307094. Pds5a.

Phylogenomic databases

eggNOGiKOG1525. Eukaryota.
ENOG410XQW7. LUCA.
GeneTreeiENSGT00390000012488.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiA4L9P7.
KOiK11267.
OMAiTCFDIVS.
OrthoDBiEOG73Z2SD.
PhylomeDBiA4L9P7.
TreeFamiTF106415.

Enzyme and pathway databases

ReactomeiR-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2468052. Establishment of Sister Chromatid Cohesion.
R-RNO-2470946. Cohesin Loading onto Chromatin.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.

Miscellaneous databases

PROiA4L9P7.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hagemann C., Stojic J., Weigelin B., Gerngras S., Roosen K., Vince G.H.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pheochromocytoma.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1174, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDS5A_RAT
AccessioniPrimary (citable) accession number: A4L9P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 1, 2007
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.