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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

Pds5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-2467813 Separation of Sister Chromatids
R-RNO-2468052 Establishment of Sister Chromatid Cohesion
R-RNO-2470946 Cohesin Loading onto Chromatin
R-RNO-2500257 Resolution of Sister Chromatid Cohesion

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
Gene namesi
Name:Pds5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1307094 Pds5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963431 – 1333Sister chromatid cohesion protein PDS5 homolog AAdd BLAST1333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei1096PhosphoserineBy similarity1
Modified residuei1145N6-acetyllysineBy similarity1
Modified residuei1174PhosphoserineCombined sources1
Modified residuei1194PhosphoserineBy similarity1
Modified residuei1207PhosphothreonineBy similarity1
Modified residuei1210N6-acetyllysineBy similarity1
Modified residuei1289N6-acetyllysineBy similarity1
Modified residuei1304PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA4L9P7
PeptideAtlasiA4L9P7
PRIDEiA4L9P7

PTM databases

CarbonylDBiA4L9P7
iPTMnetiA4L9P7
PhosphoSitePlusiA4L9P7

Expressioni

Gene expression databases

BgeeiENSRNOG00000002541

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003437

Structurei

3D structure databases

ProteinModelPortaliA4L9P7
SMRiA4L9P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati392 – 428HEATSequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
GeneTreeiENSGT00390000012488
HOGENOMiHOG000230672
HOVERGENiHBG108241
InParanoidiA4L9P7
KOiK11267
OMAiTIEPCIA
OrthoDBiEOG091G00ZG
PhylomeDBiA4L9P7
TreeFamiTF106415

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 4 hits

Sequencei

Sequence statusi: Complete.

A4L9P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT
60 70 80 90 100
FMDMDQDSED EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY
110 120 130 140 150
APEAPYTSHD KLKDIFLFIT RQLKGLEDTK SPQFNRYFYL LENLAWVKSY
160 170 180 190 200
NICFELEDCN EIFIQLFRTL FSVINNSHNK KVQMHMLDLM SSIIMEGDGV
210 220 230 240 250
TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA CIANFFNQVL
260 270 280 290 300
VLGRSSVSDL SEHVFDLIQE LFAIDPHLLL SVMPQLEFKL KSNDGEERLA
310 320 330 340 350
VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL
360 370 380 390 400
MNHPDLAKDL TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG
410 420 430 440 450
FVRERTLDKR WRVRKEAMMG LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL
460 470 480 490 500
HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE ERMKCLYYLY ASLDPNAVKA
510 520 530 540 550
LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT IAKNLPDPGK
560 570 580 590 600
AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADICVR EIARKLANPK
610 620 630 640 650
QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS
660 670 680 690 700
PDSAIRSGLE LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI
710 720 730 740 750
FRNTGHKIET DLPQIRSTLI PILHQKAKRG TPHQAKQAVH CIHAIFSNKE
760 770 780 790 800
VQLAQIFEPL SRSLNADVPE QLITPLVSLG HISMLAPDQF ASPMKSVVAN
810 820 830 840 850
FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVQAIKL LVRWLLGMKN
860 870 880 890 900
NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ
910 920 930 940 950
EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA
960 970 980 990 1000
IFALCAKDPV KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV
1010 1020 1030 1040 1050
VPYMIHLLAH DPDFTRSQDV DQLRDIKECL WFMLEVLMTK NENNSHAFMK
1060 1070 1080 1090 1100
KMAENIKLTR DAQSPDEAKT NEKLYTVCDV ALCVINSKSA LCNADSPKDP
1110 1120 1130 1140 1150
VLPMKFFTQP EKDFSNDKSY ISEETRVLLL TGKPKPTGVL GTVNKPLSAT
1160 1170 1180 1190 1200
GRKPYVRSAG TETGSNINAS SELSPSAGNR SREQSSEASE TGVSENEENP
1210 1220 1230 1240 1250
VRIISVTPVK SIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQQ
1260 1270 1280 1290 1300
KPDEKADESG PPAPSKPRRG RRPKSESQGN ATKNDDLSKP VSKGRKRAAG
1310 1320 1330
SQESLEAGNA KAPKLQDGAK KAVPAERQID LQR
Length:1,333
Mass (Da):150,286
Last modified:May 1, 2007 - v1
Checksum:iAC6FC6215E0F7F56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF460313 mRNA Translation: ABO47655.1
RefSeqiNP_001077093.1, NM_001083624.1
UniGeneiRn.224580
Rn.24482

Genome annotation databases

EnsembliENSRNOT00000003437; ENSRNOP00000003437; ENSRNOG00000002541
GeneIDi305343
KEGGirno:305343
UCSCiRGD:1307094 rat

Similar proteinsi

Entry informationi

Entry nameiPDS5A_RAT
AccessioniPrimary (citable) accession number: A4L9P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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