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Protein

Beta-crystallin A2

Gene

CRYBA2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin A2
Alternative name(s):
Beta-A2 crystallin
Gene namesi
Name:CRYBA2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002896111 – 197Beta-crystallin A2Add BLAST197

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000183.

Structurei

3D structure databases

ProteinModelPortaliA4L9I9.
SMRiA4L9I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 52Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST41
Domaini53 – 99Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST47
Domaini106 – 147Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini148 – 196Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 11N-terminal armAdd BLAST11
Regioni100 – 105Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IH1M. Eukaryota.
ENOG4110S6G. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiA4L9I9.
OMAiFGTQAHT.
OrthoDBiEOG091G0JYH.
TreeFamiTF331401.

Family and domain databases

InterProiView protein in InterPro
IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
PfamiView protein in Pfam
PF00030. Crystall. 2 hits.
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiView protein in SMART
SM00247. XTALbg. 2 hits.
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiView protein in PROSITE
PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.

Sequencei

Sequence statusi: Complete.

A4L9I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSASAPGPA PACLTLWDEE DFQGRRCRLL SDCANVGERG GLRRVRSVKV
60 70 80 90 100
ENGAWVAFEY PDFQGQQFIL EKGDYPRWSA WSGSSGHHSN QLLSFRPVLC
110 120 130 140 150
ANHSDSRVTL FEGENFQGCK FELSDDYPSL PSMGWASKEV GSLKVSSGAW
160 170 180 190
VAYQYPGYRG YQYVLERDRH SGEFRNYSEF GTQAHTGQLQ SIRRVQH
Length:197
Mass (Da):22,213
Last modified:May 1, 2007 - v1
Checksum:iA011C40966822804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF457886 mRNA. Translation: ABO41862.1.
RefSeqiNP_001093440.1. NM_001099970.1.
UniGeneiOcu.3908.

Genome annotation databases

EnsembliENSOCUT00000000206; ENSOCUP00000000183; ENSOCUG00000000206.
GeneIDi100101619.
KEGGiocu:100101619.

Similar proteinsi

Entry informationi

Entry nameiCRBA2_RABIT
AccessioniPrimary (citable) accession number: A4L9I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2007
Last modified: June 7, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families