A4KLK8 (A4KLK8_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add HAMAP MF_00540
ORF Names:	TBHG_03250 EMBL EBA43493.1

Organism

Mycobacterium tuberculosis str. Haarlem EMBL EBA43493.1

Taxonomic identifier

395095 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 SAAS SAAS006330
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540 SAAS SAAS006330
Ligand	Metal-binding HAMAP MF_00540 SAAS SAAS006330 Zinc HAMAP MF_00540 SAAS SAAS006330
Molecular function	Hydrolase HAMAP MF_00540 SAAS SAAS006330 EMBL EBA43493.1
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	211	1	Proton donor By similarity HAMAP MF_00540
	Metal binding	19	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	21	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	208	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	300	1	Zinc; catalytic By similarity HAMAP MF_00540
	Binding site	21	1	Substrate By similarity HAMAP MF_00540
	Binding site	23	1	Substrate By similarity HAMAP MF_00540
	Binding site	181	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
	Site	232	1	Important for catalytic activity By similarity HAMAP MF_00540

Sequences

	Sequence		Length	Mass (Da)
	A4KLK8 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: C034CDCEC377BB29	FASTA	365	39,743
	10 20 30 40 50 60 MTAAPTLQTI RLAPKALLHD HLDGGLRPAT VLDIAGQVGY DDLPATDVDA LASWFRTQSH 70 80 90 100 110 120 SGSLERYLEP FSHTVAVMQT PEALYRVAFE CAQDLAADSV VYAEVRFAPE LHISCGLSFD 130 140 150 160 170 180 DVVDTVLTGF AAGEKACAAD GQPITVRCLV TAMRHAAMSR EIAELAIRFR DKGVVGFDIA 190 200 210 220 230 240 GAEAGHPPTR HLDAFEYMRD HNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI 250 260 270 280 290 300 DVDADGGFQL GRLAAILRDK RIPLELCPSS NVQTGAVASI AEHPFDLLAR ARFRVTVNTD 310 320 330 340 350 360 NRLMSDTSMS LEMHRLVEAF GYGWSDLARF TVNAMKSAFI PFDQRLAIID EVIKPRFAAL MGHSE

References

[1]

"The Genome Sequence of Mycobacterium tuberculosis Haarlem." The Broad Institute Genome Sequencing Platform Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E., Brockman W., Rounsley S., Young S., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Zeng Q., Kodira C., Yandava C., O'Leary S., Alvarado L., Murray M., Kreiswirth B. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Haarlem EMBL EBA43493.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS016977 Genomic DNA. Translation: EBA43493.1.
3D structure databases
ProteinModelPortal	A4KLK8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	30819655. VBIMycTub106824_3564.
Phylogenomic databases
OMA	PYYMAMN.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4KLK8_MYCTU

Accession

Primary (citable) accession number: A4KLK8

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)