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Protein

Acetaldehyde dehydrogenase 2

Gene

Bcep1808_7604

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei272NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Bcep1808_7604
Encoded oniPlasmid pBVIE040 Publication
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Plasmid pBVIE04

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876431 – 303Acetaldehyde dehydrogenase 2Add BLAST303

Proteomic databases

PRIDEiA4JW24.

Structurei

3D structure databases

ProteinModelPortaliA4JW24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK18366.
OMAiQRSEWLE.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A4JW24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIKCALIG PGNIGTDLLA KLKRSSVLEP VWMVGIDPES EGLKRARELG
60 70 80 90 100
VKTTAEGVDG LLPHVLADGV QIAFDATSAY VHAENARKLN ALGVMMIDLT
110 120 130 140 150
PAAIGPYCVP PVNLKEHLGK REMNVNMVTC GGQATIPMVA AVSRVQPVAY
160 170 180 190 200
AEIVATVSSR SVGPGTRKNI DEFTRTTAGA VEKVGGARKG KAIIIINPAE
210 220 230 240 250
PPLMMRDTIH CLTETEPDQQ RITESIHAMI EEVQKYVPGY RLVNGPVFDG
260 270 280 290 300
KRVTVFMEVA GLGDYLPTYA GNLDIMTAAA ARTAEMFAEE MIAGNLTLEP

VVA
Length:303
Mass (Da):32,376
Last modified:May 1, 2007 - v1
Checksum:i95FA82383D1AFCFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000620 Genomic DNA. Translation: ABO60477.1.
RefSeqiWP_011875732.1. NC_009228.1.

Genome annotation databases

EnsemblBacteriaiABO60477; ABO60477; Bcep1808_7604.
KEGGibvi:Bcep1808_7604.
PATRICi19310721. VBIBurVie89221_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000620 Genomic DNA. Translation: ABO60477.1.
RefSeqiWP_011875732.1. NC_009228.1.

3D structure databases

ProteinModelPortaliA4JW24.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA4JW24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO60477; ABO60477; Bcep1808_7604.
KEGGibvi:Bcep1808_7604.
PATRICi19310721. VBIBurVie89221_0386.

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK18366.
OMAiQRSEWLE.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACDH2_BURVG
AccessioniPrimary (citable) accession number: A4JW24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.