Reviewed, UniProtKB/Swiss-Prot A4JPX8 (ACDH1_BURVG)

Names and origin

Protein names

Recommended name:
    Acetaldehyde dehydrogenase 1
    EC=1.2.1.10
Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1

Gene names

Ordered Locus Names:

Bcep1808_5385

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Acetaldehyde dehydrogenase 1 HAMAP MF_01657		PRO_0000337976

Sequences

	Sequence		Length	Mass (Da)
	A4JPX8-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 8195AFD83A71D876	FASTA	315	32,679
	10 20 30 40 50 60 MATDNTRCKA AIIGSGNIGT DLMIKIMRSG KHLEIAAMVG IDPASDGLAR AARLGVATTH 70 80 90 100 110 120 EGVEGLARLP VFDEIDFVFD ATSAGAHVKN DAFLRALKPG IRMIDLTPAA IGPYCVPVVN 130 140 150 160 170 180 LDAHLDAPNV NMVTCGGQAT IPMVAAVSRV AKVHYAEIVA SISSKSAGPG TRANIDEFTE 190 200 210 220 230 240 TTSKALEAVG GAGKGKAIIV LNPAEPPLMM RDTVYLLSEA ADRALIEASV SEMAAAVQAY 250 260 270 280 290 300 VPGYRLKQSV QFDDIPAAAP LHIPGLGRFS GLKTSIFVEV EGAAHYLPAY AGNLDIMTSA 310 ALATAERMAA SLVNA

References

[1]

"Complete sequence of chromosome 2 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000615 Genomic DNA. Translation: ABO58331.1.
RefSeq	YP_001117796.1.
3D structure databases
SMR	A4JPX8. Positions 5-315.
ModBase	Search...
Protein-protein interaction databases
STRING	A4JPX8.
Genome annotation databases
GeneID	4951603.
GenomeReviews	Gene locus Bcep1808_5385 in contig CP000615_GR.
KEGG	bvi:Bcep1808_5385.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HBG300125.
OMA	HVKNDAF.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH1_BURVG

Accession

Primary (citable) accession number: A4JPX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	May 1, 2007
Last modified:	February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)