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A4JPX8 (ACDH1_BURVG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Ordered Locus Names:Bcep1808_5385
OrganismBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]
Taxonomic identifier269482 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657
PRO_0000337976

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding166 – 1749NAD By similarity

Sites

Active site1351Acyl-thioester intermediate By similarity
Binding site2931NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A4JPX8 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 8195AFD83A71D876

FASTA31532,679
        10         20         30         40         50         60 
MATDNTRCKA AIIGSGNIGT DLMIKIMRSG KHLEIAAMVG IDPASDGLAR AARLGVATTH 

        70         80         90        100        110        120 
EGVEGLARLP VFDEIDFVFD ATSAGAHVKN DAFLRALKPG IRMIDLTPAA IGPYCVPVVN 

       130        140        150        160        170        180 
LDAHLDAPNV NMVTCGGQAT IPMVAAVSRV AKVHYAEIVA SISSKSAGPG TRANIDEFTE 

       190        200        210        220        230        240 
TTSKALEAVG GAGKGKAIIV LNPAEPPLMM RDTVYLLSEA ADRALIEASV SEMAAAVQAY 

       250        260        270        280        290        300 
VPGYRLKQSV QFDDIPAAAP LHIPGLGRFS GLKTSIFVEV EGAAHYLPAY AGNLDIMTSA 

       310 
ALATAERMAA SLVNA 

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia vietnamiensis G4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Tiedje J., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G4 / LMG 22486.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000615 Genomic DNA. Translation: ABO58331.1.
RefSeqYP_001117796.1. NC_009255.1.

3D structure databases

ProteinModelPortalA4JPX8.
SMRA4JPX8. Positions 5-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING269482.Bcep1808_5385.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO58331; ABO58331; Bcep1808_5385.
GeneID4951603.
KEGGbvi:Bcep1808_5385.
PATRIC19318236. VBIBurVie89221_4132.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAMIKVIRH.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycBVIE269482:GJNA-5468-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_BURVG
AccessionPrimary (citable) accession number: A4JPX8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 1, 2007
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families