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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei104 – 1041Transition state stabilizerUniRule annotation
Active sitei108 – 1081Proton acceptorUniRule annotation
Metal bindingi269 – 2691Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-5297-MONOMER.

Protein family/group databases

PeroxiBasei2701. BviCP02.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:Bcep1808_5214
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828UniRule annotationAdd
BLAST
Chaini29 – 741713Catalase-peroxidase 2PRO_5000232530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki107 ↔ 228Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-254)UniRule annotation
Cross-linki228 ↔ 254Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi269482.Bcep1808_5214.

Structurei

3D structure databases

ProteinModelPortaliA4JPG0.
SMRiA4JPG0. Positions 34-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4JPG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRNRIAKSV LAALAVIAMS AGSISARADG APRANGFWWP ETLDLSPLRQ
60 70 80 90 100
HDVESNPYGK DFDYAQAFQK LDIEAVKKDI RTTLTTSQDW WPADYGNYGP
110 120 130 140 150
FFIRMAWHGA GTYRTYDGRG GAGGAQQRFE PLNSWPDNAN LDKARRLLWP
160 170 180 190 200
IKKKYGQNIS WGDLMVLTGN VALESMGFQT FGFGGGREDD WQSDLVYWGA
210 220 230 240 250
GPKFMSNNRD KNGKLEKPLA ATQMGLIYVN PEGPNGNPDP VAAAQDIREA
260 270 280 290 300
FGRMAMNDEE TLALIAGGHT FGKAHGAASP DKCVGVAPAG AGVEAQGLGW
310 320 330 340 350
ANKCGTGKGV DTITSGLEGA WSVDPVHFTM QYLDNLLGHD WVLTKSPAGA
360 370 380 390 400
HQWMPKDAQS IVPDAHDPSK LHPLMMFTTD IALKVDPAYS KIAKRFEEHP
410 420 430 440 450
DEFKLAFAKA WFKLTHRDLG PKARYLGKDV PKVDLIWQDP LPVAGYQTIG
460 470 480 490 500
AADIADLKSR ILASGLPKSE LIKTAWASAA SFRGTDYRGG ANGARIRLAP
510 520 530 540 550
ENGWAVNDPA SVAKVLKSLE AIQSGFNKGR TDGKQVSLAD LIVLGGSAAV
560 570 580 590 600
EDAARKAGYD ITVPFAPGRV DATQAQTDVA SFAVLEPTAD GFRNYYQKGN
610 620 630 640 650
ERSPAELLVD RASKLDLTVP EMTVLVGGLR ALDANTGHSK LGVLTNHPGT
660 670 680 690 700
LSNEFFVNLL DMSTEWKKSP SADGTYEGRD RKTGALRWTA SPVDLVFGSS
710 720 730 740
SELRAVAEVY ASDDAHEKFV RDFVAAWTKV MNLDRFDLKR I
Length:741
Mass (Da):80,509
Last modified:May 1, 2007 - v1
Checksum:iD9D4B4A38E9E7964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000615 Genomic DNA. Translation: ABO58163.1.
RefSeqiWP_011882486.1. NC_009255.1.

Genome annotation databases

EnsemblBacteriaiABO58163; ABO58163; Bcep1808_5214.
KEGGibvi:Bcep1808_5214.
PATRICi19317874. VBIBurVie89221_3951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000615 Genomic DNA. Translation: ABO58163.1.
RefSeqiWP_011882486.1. NC_009255.1.

3D structure databases

ProteinModelPortaliA4JPG0.
SMRiA4JPG0. Positions 34-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269482.Bcep1808_5214.

Protein family/group databases

PeroxiBasei2701. BviCP02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO58163; ABO58163; Bcep1808_5214.
KEGGibvi:Bcep1808_5214.
PATRICi19317874. VBIBurVie89221_3951.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-5297-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG2_BURVG
AccessioniPrimary (citable) accession number: A4JPG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.