Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4JLT5 (GCH4_BURVG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Bcep1808_4258
OrganismBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]
Taxonomic identifier269482 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_1000068663

Sites

Site1541May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A4JLT5 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 1B2A7D05618A18BC

FASTA26930,152
        10         20         30         40         50         60 
MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVCT ESGDVQPSVG VWNLDVRLPA 

        70         80         90        100        110        120 
DQKGTHMSRF VALLEENRAP LTVERFRAML ASMLEKLEAQ AGRIEVTFPY FVNKTAPVSG 

       130        140        150        160        170        180 
VQSLLDYEVT LAGESRDGHT RVFLKVLVPV TSLCPCSKKI SQYGAHNQRS HVTIDAELAG 

       190        200        210        220        230        240 
DLPVEALIRI AEEEASCELW GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLDADERVI 

       250        260 
AYVLEAENFE SIHNHSAYAL IERDKRLAA 

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia vietnamiensis G4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Tiedje J., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G4 / LMG 22486.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000615 Genomic DNA. Translation: ABO57238.1.
RefSeqYP_001116703.1. NC_009255.1.

3D structure databases

ProteinModelPortalA4JLT5.
SMRA4JLT5. Positions 21-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING269482.Bcep1808_4258.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO57238; ABO57238; Bcep1808_4258.
GeneID4950475.
KEGGbvi:Bcep1808_4258.
PATRIC19315985. VBIBurVie89221_3006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycBVIE269482:GJNA-4339-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BURVG
AccessionPrimary (citable) accession number: A4JLT5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways