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Protein

Malate dehydrogenase 1

Gene

mdh1

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei106NADUniRule annotation1
Binding sitei113NADUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi130 – 132NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 1UniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdh1UniRule annotation
Ordered Locus Names:Bcep1808_3766
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003155451 – 328Malate dehydrogenase 1Add BLAST328

Interactioni

Protein-protein interaction databases

STRINGi269482.Bcep1808_3766.

Structurei

3D structure databases

ProteinModelPortaliA4JKE6.
SMRiA4JKE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000220953.
KOiK00024.
OMAiYPDVHHC.
OrthoDBiPOG091H02N6.

Family and domain databases

HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

A4JKE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPARRVAV TGAAGQIAYS LLFRIARGDL LGDDQPVILQ LLELPHALDA
60 70 80 90 100
LRGVVMELED CAFPLLQSVE ISDDPRVAFR DADYAMLVGS RPRGKGMERR
110 120 130 140 150
DLLAANAAIF RSQGEALNEV ANRQVKVLVV GNPANTNAWV ARHYAPDLPA
160 170 180 190 200
DAITAMIRLD HNRAVSKLAA RCGVTVDAVS RMAVWGNHSP TMFPDYRHAL
210 220 230 240 250
IDQQPAPMRV GDERWYLDTF IPEVARRGTA IIEARGASSA ASAANAAIDQ
260 270 280 290 300
MRDWIRGSGG RWVSMSIVSG GEYGIPRGLM FGMPTICSEG RYRVVPDLEI
310 320
DALARARIDA SVAELVDEMQ AVRAILAL
Length:328
Mass (Da):35,654
Last modified:May 1, 2007 - v1
Checksum:iA861F980DA9E8285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000615 Genomic DNA. Translation: ABO56749.1.

Genome annotation databases

EnsemblBacteriaiABO56749; ABO56749; Bcep1808_3766.
KEGGibvi:Bcep1808_3766.

Similar proteinsi

Entry informationi

Entry nameiMDH1_BURVG
AccessioniPrimary (citable) accession number: A4JKE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: September 27, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families