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A4JJS1 (METE_BURVG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:Bcep1808_3537
OrganismBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]
Taxonomic identifier269482 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7677675-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_1000017233

Sites

Metal binding6501Zinc By similarity
Metal binding6521Zinc By similarity
Metal binding7351Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A4JJS1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: A4CF72720A653F27

FASTA76785,940
        10         20         30         40         50         60 
MVKTHNLGFP RIGAQRELKF GLERYWNGDA TRDELTALGA ALRRRHWSDQ RDLDLAPLGD 

        70         80         90        100        110        120 
FAFYDHVLDM SFTLGNLPKR VQDFHGDALD NYFRVARGRS AHSAHEHASC CGGVAAGEMT 

       130        140        150        160        170        180 
KWFDTNYHYI VPEFHADTNF SLDPSRLLQQ LAEANAQRVN AKPVILGPVT YLWLGKAKDD 

       190        200        210        220        230        240 
SDRLALLPKL LPVYGALLDT LTAQGVEWVQ IDEPILVTEL DADWRRALRT AYEALETRRI 

       250        260        270        280        290        300 
KLLLATYFGQ LQDNLELAVS LPVDGLHIDA VNARDEVDAL ARALPPTRVL SVGAIDGRNI 

       310        320        330        340        350        360 
WRTDLNAALD WLEPLARQLG ERLWLAPSCS LLHVPVDLAS EQKLDAEIRS WLAFALQKLA 

       370        380        390        400        410        420 
ELKLLATALN QGRDTVADAL AENAAAIESR RRSPRVHNPA VKSAVARIDA RLGNRASAYP 

       430        440        450        460        470        480 
QRAAAQSARL KLPLFPTTTI GSFPQTAEIR DARRRFKAGE LDEAGYRHAM HAEIERSVRE 

       490        500        510        520        530        540 
QESLQLDVLV HGEAERNDMV EYFGEQLDGY AFSQFGWVQS YGSRCVKPPI LFGDISRPSA 

       550        560        570        580        590        600 
MTVEWIAYAQ SLTSKPMKGM LTGPVTILNW SFVRDDQPRS VSCYQLALAI RDEVLDLERA 

       610        620        630        640        650        660 
GVRVIQIDEA ALREGLPLRR AQWPAYLKWA IDAFRIAANG VRDDTQIHTH MCYSEFNDII 

       670        680        690        700        710        720 
ASIAEMDADV ITIETSRSDM ELLDAFDGFR YPNEIGPGVY DIHSPNIPTQ EHIVGLMRKA 

       730        740        750        760 
AERIPAQRLW VNPDCGLKTR RWAEVLPALT NMVAAAKTLR SELRNGL 

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References

[1]"Complete sequence of chromosome 2 of Burkholderia vietnamiensis G4."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Tiedje J., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G4 / LMG 22486.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000615 Genomic DNA. Translation: ABO56524.1.
RefSeqYP_001115989.1. NC_009255.1.

3D structure databases

ProteinModelPortalA4JJS1.
SMRA4JJS1. Positions 3-762.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4JJS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4949749.
GenomeReviewsGene locus Bcep1808_3537 in contig CP000615_GR.
KEGGbvi:Bcep1808_3537.
PATRIC19314426. VBIBurVie89221_2232.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycBVIE269482:BCEP1808_3537-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_BURVG
AccessionPrimary (citable) accession number: A4JJS1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families