Reviewed, UniProtKB/Swiss-Prot A4JJG5 (BETB_BURVG)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Bcep1808_3430

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Betaine aldehyde dehydrogenase		PRO_1000047041
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	251	1	By similarity
	Active site	285	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4JJG5-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 8B33A3AEA4223651	FASTA	489	52,239
	10 20 30 40 50 60 MSVYGLQRLY IGGAYVDATS GKTFDTFDPA TGELLAQVQQ ASAADVDRAV ASAQQGQREW 70 80 90 100 110 120 AALTAMQRSR ILRRAVDLLR ERNDELAAIE TRDTGKPIGE TLAVDIVTGA DVIEYYAGLA 130 140 150 160 170 180 TAIEGLQVPL RAESFVYTRR EPLGVCAGIG AWNYPIQIAC WKTAPALAAG NAMVFKPSEV 190 200 210 220 230 240 TPLTALKLAE IYTEAGVPAG VFNVVQGDGS VGALLTGHPD IAKVSFTGGV ETGKKVMSLA 250 260 270 280 290 300 GASSLKEVTM ELGGKSPLIV FDDADLDRAA DIAVIANFFS SGQVCTNGTR VFVQRSIKDA 310 320 330 340 350 360 FTAKVLERVK RIRVGKPTDA DTNFGPLVSA AQLDKVLGFI ASGKAEGAKL LAGGTRLTDG 370 380 390 400 410 420 HFADGQYVAP TVFGDCRDDM KIVREEIFGP VMSILDFESE DEVIARANDT HYGLAAGVVT 430 440 450 460 470 480 ENLSRAHRTI HRLEAGICWI NTWGESPAEM PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGRYNPVF

References

[1]

"Complete sequence of chromosome 2 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000615 Genomic DNA. Translation: ABO56418.1.
RefSeq	YP_001115883.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4949642.
GenomeReviews	Gene locus Bcep1808_3430 in contig CP000615_GR.
KEGG	bvi:Bcep1808_3430.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR011264. Betaine_Ald_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_BURVG

Accession

Primary (citable) accession number: A4JJG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	November 4, 2008
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)