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Reviewed, UniProtKB/Swiss-Prot A4JHT1 (QUEF_BURVG)

Last modified November 25, 2008. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADPH-dependent 7-cyano-7-deazaguanine reductase
    EC=1.7.1.13
Alternative name(s):
    7-cyano-7-carbaguanine reductase
    PreQ(0) reductase
    NADPH-dependent nitrile oxidoreductase
Gene names
Name: queF
Ordered Locus Names: Bcep1808_2843
OrganismBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]
Taxonomic identifier269482 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity.

Catalytic activity

7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-carbaguanine + 2 NADPH.

Pathway

tRNA modification; queuosine-tRNA biosynthesis.

Subcellular location

CytoplasmProbable.

Sequence similarities

Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274NADPH-dependent 7-cyano-7-deazaguanine reductase
PRO_1000062335

Sequences

Sequence LengthMass (Da)Tools
A4JHT1-1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 0ED5A700F3AF5B80

FASTA27430,291
        10         20         30         40         50         60 
MNPEHSPLGK ATVYAAQYDA SLLFPIPRAG AREQLGIAAA LPFFGTDIWN AYELSWLNAR 

        70         80         90        100        110        120 
GKPQLAVATF YVPAESPNIV ESKSFKLYLG SFAQSKFDSV DAVRDVLKRD VSAACGASVS 

       130        140        150        160        170        180 
VQLVSPHDFG KLQMEELDGL SLDRLDLDTD VYEPDPSLLS AAADEAPVEE TLVSDLLRSN 

       190        200        210        220        230        240 
CPVTGQPDWG SVQIHYVGPQ IDHAGLLRYI ISFRNHTGFH EQCVERIFLD ILQACKPLKL 

       250        260        270 
AVYARYTRRG GLDINPFRTN YNQSMPDNAR TARQ 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Tiedje J., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000614 Genomic DNA. Translation: ABO55834.1.
RefSeqYP_001120669.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4954588.
GenomeReviewsGene locus Bcep1808_2843 in contig CP000614_GR.
KEGGbvi:Bcep1808_2843.

Organism-specific databases

CMRSearch...

Family and domain databases

HAMAPMF_00817.
[Tree]
InterProIPR016428. CN_OxRdtase_NADPH-dep_YqcD.
IPR001474. GTP_CycOHase_I.
[Graphical view]
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
PIRSFPIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
TIGRFAMsTIGR03138. QueF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQUEF_BURVG
AccessionPrimary (citable) accession number: A4JHT1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents