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Protein

Ribosomal RNA large subunit methyltransferase H

Gene

rlmH

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N3-methylpseudouridine(1915) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei104S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase HUniRule annotation (EC:2.1.1.177UniRule annotation)
Alternative name(s):
23S rRNA (pseudouridine1915-N3)-methyltransferaseUniRule annotation
23S rRNA m3Psi1915 methyltransferaseUniRule annotation
rRNA (pseudouridine-N3-)-methyltransferase RlmHUniRule annotation
Gene namesi
Name:rlmHUniRule annotation
Ordered Locus Names:Bcep1808_2384
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000617691 – 156Ribosomal RNA large subunit methyltransferase HAdd BLAST156

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi269482.Bcep1808_2384.

Structurei

3D structure databases

ProteinModelPortaliA4JGI0.
SMRiA4JGI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni123 – 128S-adenosyl-L-methionine bindingUniRule annotation6

Sequence similaritiesi

Belongs to the RNA methyltransferase RlmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UXA. Bacteria.
COG1576. LUCA.
HOGENOMiHOG000218434.
KOiK00783.
OMAiNGEPYHK.
OrthoDBiPOG091H028B.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00658. 23SrRNA_methyltr_H. 1 hit.
InterProiView protein in InterPro
IPR029028. Alpha/beta_knot_MTases.
IPR003742. RlmH-like.
IPR029026. tRNA_m1G_MTases_N.
PANTHERiPTHR33603. PTHR33603. 1 hit.
PfamiView protein in Pfam
PF02590. SPOUT_MTase. 1 hit.
PIRSFiPIRSF004505. MT_bac. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00246. tRNA_RlmH_YbeA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4JGI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYILAVGH KMPGWIASGF DEYTKRMPPE LRIELREIKP ELRSGGRSAE
60 70 80 90 100
SVMAAERQKI EAALPKGARI VALDERGRDW TTMQLAQALP GWQQDGRDVA
110 120 130 140 150
FVIGGADGLD PELKARADLL LRISSMTLPH GMVRVLLAEQ LYRAWSITQN

HPYHRA
Length:156
Mass (Da):17,528
Last modified:May 1, 2007 - v1
Checksum:i488A3C0137CDDB98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000614 Genomic DNA. Translation: ABO55383.1.

Genome annotation databases

EnsemblBacteriaiABO55383; ABO55383; Bcep1808_2384.
KEGGibvi:Bcep1808_2384.

Similar proteinsi

Entry informationi

Entry nameiRLMH_BURVG
AccessioniPrimary (citable) accession number: A4JGI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families