A4JCM8 (PNCB_BURVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	Bcep1808_1020

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia vietnamiensis

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000025000

Sequences

	Sequence		Length	Mass (Da)
	A4JCM8 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 24AD899A4177FA31	FASTA	399	46,014
	10 20 30 40 50 60 MIITSLLDTD LYKFTMMQVV LHHFPAATVE YRFRCRTRGV DLVPYIDEIR DEVRGLCALR 70 80 90 100 110 120 FTDVELDYLR RMRFIKSDFV DFLALFHLNE KYISIMPSPK GNGEIDIVIE GPWLHTILFE 130 140 150 160 170 180 IPVLAIVNEV YFRNTQREPD YREGRERLRD KIKLLGAKPE FADCKIADYG TRRRFSKVWH 190 200 210 220 230 240 EEVALTLRDG LGPQFAGTSN VFYAMKHDLT PLGTMAHEYL QACQALGPRL RDSQTYGFEM 250 260 270 280 290 300 WAKEYRGDLG IALSDVYGMD AFLNDFDMYF CKLFDGARHD SGDPFDWGER MLRHYEANRC 310 320 330 340 350 360 DPRTKVLVFS DALDIPKVMQ LYERFRGRCK LAFGVGTNLT NDLGYVPLQI VIKMVRCNGQ 370 380 390 PVAKLSDSPG KSMCDDKAYL AYLRQVFGIA QPVGDDASQ

References

[1]

"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G4 / LMG 22486.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000614 Genomic DNA. Translation: ABO54031.1.
RefSeq	YP_001118866.1. NC_009256.1.
3D structure databases
ProteinModelPortal	A4JCM8.
ModBase	Search...
Protein-protein interaction databases
STRING	269482.Bcep1808_1020.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABO54031; ABO54031; Bcep1808_1020.
GeneID	4952726.
KEGG	bvi:Bcep1808_1020.
PATRIC	19320545. VBIBurVie89221_5252.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284928.
KO	K00763.
OMA	SFGWGTN.
ProtClustDB	PRK05321.
Enzyme and pathway databases
BioCyc	BVIE269482:GJNA-1053-MONOMER.
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_BURVG

Accession

Primary (citable) accession number: A4JCM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program