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A4JCM8

- PNCB_BURVG

UniProt

A4JCM8 - PNCB_BURVG

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBVIE269482:GJNA-1053-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:Bcep1808_1020
    OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
    Taxonomic identifieri269482 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002287: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Nicotinate phosphoribosyltransferasePRO_1000025000Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269482.Bcep1808_1020.

    Structurei

    3D structure databases

    ProteinModelPortaliA4JCM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4JCM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIITSLLDTD LYKFTMMQVV LHHFPAATVE YRFRCRTRGV DLVPYIDEIR    50
    DEVRGLCALR FTDVELDYLR RMRFIKSDFV DFLALFHLNE KYISIMPSPK 100
    GNGEIDIVIE GPWLHTILFE IPVLAIVNEV YFRNTQREPD YREGRERLRD 150
    KIKLLGAKPE FADCKIADYG TRRRFSKVWH EEVALTLRDG LGPQFAGTSN 200
    VFYAMKHDLT PLGTMAHEYL QACQALGPRL RDSQTYGFEM WAKEYRGDLG 250
    IALSDVYGMD AFLNDFDMYF CKLFDGARHD SGDPFDWGER MLRHYEANRC 300
    DPRTKVLVFS DALDIPKVMQ LYERFRGRCK LAFGVGTNLT NDLGYVPLQI 350
    VIKMVRCNGQ PVAKLSDSPG KSMCDDKAYL AYLRQVFGIA QPVGDDASQ 399
    Length:399
    Mass (Da):46,014
    Last modified:May 1, 2007 - v1
    Checksum:i24AD899A4177FA31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO54031.1.
    RefSeqiYP_001118866.1. NC_009256.1.

    Genome annotation databases

    EnsemblBacteriaiABO54031; ABO54031; Bcep1808_1020.
    GeneIDi4952726.
    KEGGibvi:Bcep1808_1020.
    PATRICi19320545. VBIBurVie89221_5252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO54031.1 .
    RefSeqi YP_001118866.1. NC_009256.1.

    3D structure databases

    ProteinModelPortali A4JCM8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269482.Bcep1808_1020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO54031 ; ABO54031 ; Bcep1808_1020 .
    GeneIDi 4952726.
    KEGGi bvi:Bcep1808_1020.
    PATRICi 19320545. VBIBurVie89221_5252.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci BVIE269482:GJNA-1053-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Tiedje J., Richardson P.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G4 / LMG 22486.

    Entry informationi

    Entry nameiPNCB_BURVG
    AccessioniPrimary (citable) accession number: A4JCM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3