A4JCH4 (AROA_BURVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Bcep1808_0966

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325337

Sequences

	Sequence		Length	Mass (Da)
	A4JCH4 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: E133E0388791CDFB	FASTA	434	46,459
	10 20 30 40 50 60 MDYLDLGPYS SASGTVRLPG SKSISNRVLL LAALAEGETT ITNLLDSDDT RVMLDALGKL 70 80 90 100 110 120 GVRLTRDADT CVVAGTRGAF TARTADLFLG NAGTAVRPLT AALAVNGGDY RVHGVPRMHE 130 140 150 160 170 180 RPIGDLVDGL RQIGAQIDYE QNEGFPPLRI KPAAITVDAP IRVRGDVSSQ FLTALLMTLP 190 200 210 220 230 240 LVKAKDGKIV VEVDGELISK PYIDITIRLM ERFGVTVERD GWQRFVVPAG VRYRSPGRIM 250 260 270 280 290 300 VEGDASSASY FLAAGALGGG PLRVEGVGRA SIQGDVGFAN ALMQMGANVS MGDDWIEVRG 310 320 330 340 350 360 IGHDHGKLDP IDMDFNLIPD AAMTIAVAAL FASGTSTLRN IASWRVKETD RIAAMATELR 370 380 390 400 410 420 KLGAVVEEGP DYLVVTPPQR LTPNATIDTY DDHRMAMCFS LVSLGGVPVR INDPKCVGKT 430 FPDYFDRFAA LAKA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G4 / LMG 22486.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000614 Genomic DNA. Translation: ABO53977.1.
RefSeq	YP_001118812.1. NC_009256.1.
3D structure databases
ProteinModelPortal	A4JCH4.
ModBase	Search...
Protein-protein interaction databases
STRING	A4JCH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4952670.
GenomeReviews	Gene locus Bcep1808_0966 in contig CP000614_GR.
KEGG	bvi:Bcep1808_0966.
PATRIC	19320421. VBIBurVie89221_5192.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GADIEWG.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	BVIE269482:BCEP1808_0966-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BURVG

Accession

Primary (citable) accession number: A4JCH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program