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Protein

D-(-)-3-hydroxybutyrate oligomer hydrolase

Gene

Bcep1808_0779

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D--3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.UniRule annotation

Catalytic activityi

(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate.UniRule annotation

Pathwayi: butanoate metabolism

This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei309Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-788-MONOMER
UniPathwayiUPA00863

Names & Taxonomyi

Protein namesi
Recommended name:
D-(-)-3-hydroxybutyrate oligomer hydrolaseUniRule annotation (EC:3.1.1.22UniRule annotation)
Short name:
3HB-oligomer hydrolaseUniRule annotation
Short name:
3HBOHUniRule annotation
Gene namesi
Ordered Locus Names:Bcep1808_0779
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Chromosome 1

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26UniRule annotationAdd BLAST26
ChainiPRO_500023174327 – 696D-(-)-3-hydroxybutyrate oligomer hydrolaseAdd BLAST670

Proteomic databases

PRIDEiA4JBY8

Interactioni

Protein-protein interaction databases

STRINGi269482.Bcep1808_0779

Family & Domainsi

Sequence similaritiesi

Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BE1 Bacteria
ENOG410XSMB LUCA
HOGENOMiHOG000263490
KOiK07518
OMAiNPEKDWG
OrthoDBiPOG091H117N

Family and domain databases

HAMAPiMF_01906 3HBOH, 1 hit
InterProiView protein in InterPro
IPR016582 OHBut_olig_hydro_put
PfamiView protein in Pfam
PF10605 3HBOH, 1 hit
PIRSFiPIRSF011409 HObutyrate_olig_hydrol, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4JBY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTHGWGSRI LVGAALAALT MLGACNGDET AERNQLPVFV SGSVRTTAYD
60 70 80 90 100
GASDDLLTAG LGKTGLASAA APAFADPSRP TAAELRRVAI WSNYRALVDM
110 120 130 140 150
SANGGYGRFW GPNVDLDGND TLGEGKIAGT EYLAYADDGS GRKNVTLLVQ
160 170 180 190 200
VPASFDPAQP CIVTATSSGS RGVYGAISAA GEWGLKRGCA VAYNDKGGGN
210 220 230 240 250
GAQELGSNTV TLIDGTLANA VLAGSASLFT ANLTSGDLAA FNSRFPNRYA
260 270 280 290 300
FKHAHSQQNP EHDWGRATLQ SVEFAYWALN QQFAPLVDGS HRGVRYRAGD
310 320 330 340 350
ITTIAASVSN GGGAALAAAE QDTRRWITAV VVGEPQINVR MAPNAVVRES
360 370 380 390 400
GRPVPSFGRP LADYATLANL LEPCAAASAS LAGEPYLSAL PLATTQSIRT
410 420 430 440 450
QRCATLAAAG LVSGADTQSQ AADALAQLHA AGYLADSDLL QASMWDSQAI
460 470 480 490 500
PAIAVTYANA YTRSSVADNL CNFSFATTNA ATGAVAAPAA SPMPAVFGLG
510 520 530 540 550
NGVPPTAGIN LVFNTGAGVD HRLATPDASF AGALCLRQLW TNGMLDMPAN
560 570 580 590 600
VEAVRVNANL QGKPAIIVQG RSDALVPVNH ASRAYVAQNS ISEGGRSQLV
610 620 630 640 650
FYEVTNGQHF DAFLPVAGFD TRFVPVHYYN VQALNLMWRH LKSGAPLPPS
660 670 680 690
QVIRTVPRGG TPGAAPALTS ANLPPISTAP GANAIAAGAG AIDVPL
Length:696
Mass (Da):71,688
Last modified:May 1, 2007 - v1
Checksum:i9824C126919E25AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000614 Genomic DNA Translation: ABO53791.1

Genome annotation databases

EnsemblBacteriaiABO53791; ABO53791; Bcep1808_0779
KEGGibvi:Bcep1808_0779

Similar proteinsi

Entry informationi

Entry nameiHBOH_BURVG
AccessioniPrimary (citable) accession number: A4JBY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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