Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D-(-)-3-hydroxybutyrate oligomer hydrolase

Gene

Bcep1808_0779

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D--3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.UniRule annotation

Catalytic activityi

(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate.UniRule annotation

Pathwayi: butanoate metabolism

This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei309 – 3091Charge relay systemUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-802-MONOMER.
UniPathwayiUPA00863.

Names & Taxonomyi

Protein namesi
Recommended name:
D-(-)-3-hydroxybutyrate oligomer hydrolaseUniRule annotation (EC:3.1.1.22UniRule annotation)
Short name:
3HB-oligomer hydrolaseUniRule annotation
Short name:
3HBOHUniRule annotation
Gene namesi
Ordered Locus Names:Bcep1808_0779
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Chromosome 1

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626UniRule annotationAdd
BLAST
Chaini27 – 696670D-(-)-3-hydroxybutyrate oligomer hydrolasePRO_5000231743Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269482.Bcep1808_0779.

Family & Domainsi

Sequence similaritiesi

Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BE1. Bacteria.
ENOG410XSMB. LUCA.
HOGENOMiHOG000263490.
KOiK07518.
OMAiNPEKDWG.
OrthoDBiPOG091H117N.

Family and domain databases

Gene3Di3.40.50.1820. 4 hits.
HAMAPiMF_01906. 3HBOH. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016582. OHBut_olig_hydro_put.
[Graphical view]
PfamiPF10605. 3HBOH. 1 hit.
[Graphical view]
PIRSFiPIRSF011409. HObutyrate_olig_hydrol. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4JBY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTHGWGSRI LVGAALAALT MLGACNGDET AERNQLPVFV SGSVRTTAYD
60 70 80 90 100
GASDDLLTAG LGKTGLASAA APAFADPSRP TAAELRRVAI WSNYRALVDM
110 120 130 140 150
SANGGYGRFW GPNVDLDGND TLGEGKIAGT EYLAYADDGS GRKNVTLLVQ
160 170 180 190 200
VPASFDPAQP CIVTATSSGS RGVYGAISAA GEWGLKRGCA VAYNDKGGGN
210 220 230 240 250
GAQELGSNTV TLIDGTLANA VLAGSASLFT ANLTSGDLAA FNSRFPNRYA
260 270 280 290 300
FKHAHSQQNP EHDWGRATLQ SVEFAYWALN QQFAPLVDGS HRGVRYRAGD
310 320 330 340 350
ITTIAASVSN GGGAALAAAE QDTRRWITAV VVGEPQINVR MAPNAVVRES
360 370 380 390 400
GRPVPSFGRP LADYATLANL LEPCAAASAS LAGEPYLSAL PLATTQSIRT
410 420 430 440 450
QRCATLAAAG LVSGADTQSQ AADALAQLHA AGYLADSDLL QASMWDSQAI
460 470 480 490 500
PAIAVTYANA YTRSSVADNL CNFSFATTNA ATGAVAAPAA SPMPAVFGLG
510 520 530 540 550
NGVPPTAGIN LVFNTGAGVD HRLATPDASF AGALCLRQLW TNGMLDMPAN
560 570 580 590 600
VEAVRVNANL QGKPAIIVQG RSDALVPVNH ASRAYVAQNS ISEGGRSQLV
610 620 630 640 650
FYEVTNGQHF DAFLPVAGFD TRFVPVHYYN VQALNLMWRH LKSGAPLPPS
660 670 680 690
QVIRTVPRGG TPGAAPALTS ANLPPISTAP GANAIAAGAG AIDVPL
Length:696
Mass (Da):71,688
Last modified:May 1, 2007 - v1
Checksum:i9824C126919E25AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000614 Genomic DNA. Translation: ABO53791.1.
RefSeqiWP_011883475.1. NC_009256.1.

Genome annotation databases

EnsemblBacteriaiABO53791; ABO53791; Bcep1808_0779.
KEGGibvi:Bcep1808_0779.
PATRICi19320016. VBIBurVie89221_4997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000614 Genomic DNA. Translation: ABO53791.1.
RefSeqiWP_011883475.1. NC_009256.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269482.Bcep1808_0779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO53791; ABO53791; Bcep1808_0779.
KEGGibvi:Bcep1808_0779.
PATRICi19320016. VBIBurVie89221_4997.

Phylogenomic databases

eggNOGiENOG4106BE1. Bacteria.
ENOG410XSMB. LUCA.
HOGENOMiHOG000263490.
KOiK07518.
OMAiNPEKDWG.
OrthoDBiPOG091H117N.

Enzyme and pathway databases

UniPathwayiUPA00863.
BioCyciBVIE269482:GJNA-802-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 4 hits.
HAMAPiMF_01906. 3HBOH. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016582. OHBut_olig_hydro_put.
[Graphical view]
PfamiPF10605. 3HBOH. 1 hit.
[Graphical view]
PIRSFiPIRSF011409. HObutyrate_olig_hydrol. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHBOH_BURVG
AccessioniPrimary (citable) accession number: A4JBY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.