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A4JBW6

- HGD_BURVG

UniProt

A4JBW6 - HGD_BURVG

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Protein

Homogentisate 1,2-dioxygenase

Gene
hmgA, Bcep1808_0757
Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei298 – 2981Proton acceptor By similarity
Metal bindingi341 – 3411Iron By similarity
Metal bindingi347 – 3471Iron By similarity
Binding sitei356 – 3561homogentisate By similarity
Metal bindingi377 – 3771Iron By similarity
Binding sitei377 – 3771homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-780-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:Bcep1808_0757
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002287: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Homogentisate 1,2-dioxygenaseUniRule annotationPRO_1000019529Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi269482.Bcep1808_0757.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4JBW6-1 [UniParc]FASTAAdd to Basket

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MTLDLSKPAT AGYLSGFGNE FATEALPGAL PHGRNSPQRA PYGLYAEQLS    50
GTAFTAPRGH NRRAWLYRIR PAAVHRPFEP FTGRQRLVAE FGDSADVPPT 100
PPNQLRWDPL PMPVEPTDFV EGLVTMAGNG SAAAMNGCAI HLYAANRSMQ 150
DRFFYSADGE LLIVPQQGRL FIATEFGRLD VEPAEIAVIP RGVRFAVALP 200
DGDARGYICE NFGALLRLPD LGPIGSNGLA NPRDFLTPQA AYEDREGAFE 250
LIAKLNGRLW RADIGHSPFD VVAWHGNYAP YKYDLRLFNT IGSISYDHPD 300
PSIFLVLQSQ SDSPGVDAID FVIFPPRWLA AEDTFRPPWF HRNVASEFMG 350
LVHGAYDAKA EGFVPGGASL HNCMSGHGPD ADTFEKASAI DTTRPHKVDA 400
TMAFMFETRT LIRPTRYALD TAQLQADYFE CWQRIEKHFN PEQR 444
Length:444
Mass (Da):49,128
Last modified:May 1, 2007 - v1
Checksum:iC415A729CBB8CEE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000614 Genomic DNA. Translation: ABO53769.1.
RefSeqiYP_001118604.1. NC_009256.1.

Genome annotation databases

EnsemblBacteriaiABO53769; ABO53769; Bcep1808_0757.
GeneIDi4952453.
KEGGibvi:Bcep1808_0757.
PATRICi19319968. VBIBurVie89221_4973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000614 Genomic DNA. Translation: ABO53769.1 .
RefSeqi YP_001118604.1. NC_009256.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269482.Bcep1808_0757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO53769 ; ABO53769 ; Bcep1808_0757 .
GeneIDi 4952453.
KEGGi bvi:Bcep1808_0757.
PATRICi 19319968. VBIBurVie89221_4973.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci BVIE269482:GJNA-780-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Tiedje J., Richardson P.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G4 / LMG 22486.

Entry informationi

Entry nameiHGD_BURVG
AccessioniPrimary (citable) accession number: A4JBW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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