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A4JBT0

- PUR5_BURVG

UniProt

A4JBT0 - PUR5_BURVG

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBVIE269482:GJNA-743-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:Bcep1808_0721
    OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
    Taxonomic identifieri269482 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002287: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046431Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269482.Bcep1808_0721.

    Structurei

    3D structure databases

    ProteinModelPortaliA4JBT0.
    SMRiA4JBT0. Positions 13-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4JBT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPPKSAPDA QGLSYRDAGV DIDAGDALID KIKPFAKKTL RDGVLGGIGG    50
    FGALFEVPKK YREPVLVSGT DGVGTKLKLA FHLNKHDTVG QDLVAMSVND 100
    ILVQGAEPLF FLDYFACGKL DVDTAATVVK GIAHGCELSG CALIGGETAE 150
    MPGMYPDGEY DLAGFAVGAV EKSKIIDGST IGAGDVVLGL ASSGIHSNGF 200
    SLVRKIIERA NPDLSADFHG RSLADTLMAP TRIYVKPLLA LMQKLTVKGM 250
    AHITGGGLVE NIPRVLREGL TAELDQNAWP LPPLFKWLQE HGGVADAEMH 300
    RVFNCGIGMA VIVAAADADA AIADLTAAGE QVWKIGTVRA SREGEAQTVV 350
    V 351
    Length:351
    Mass (Da):36,772
    Last modified:May 1, 2007 - v1
    Checksum:iA996664C29C839E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO53733.1.
    RefSeqiYP_001118568.1. NC_009256.1.

    Genome annotation databases

    EnsemblBacteriaiABO53733; ABO53733; Bcep1808_0721.
    GeneIDi4952416.
    KEGGibvi:Bcep1808_0721.
    PATRICi19319885. VBIBurVie89221_4933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO53733.1 .
    RefSeqi YP_001118568.1. NC_009256.1.

    3D structure databases

    ProteinModelPortali A4JBT0.
    SMRi A4JBT0. Positions 13-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269482.Bcep1808_0721.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO53733 ; ABO53733 ; Bcep1808_0721 .
    GeneIDi 4952416.
    KEGGi bvi:Bcep1808_0721.
    PATRICi 19319885. VBIBurVie89221_4933.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BVIE269482:GJNA-743-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Tiedje J., Richardson P.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G4 / LMG 22486.

    Entry informationi

    Entry nameiPUR5_BURVG
    AccessioniPrimary (citable) accession number: A4JBT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3