Reviewed, UniProtKB/Swiss-Prot A4JBR6 (HEMH_BURVG)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	Bcep1808_0707

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Ferrochelatase HAMAP MF_00323		PRO_1000019286
Sites
	Metal binding	214	1	Iron By similarity
	Metal binding	295	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4JBR6-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: D364D40318097B72	FASTA	354	39,180
	10 20 30 40 50 60 MRFDLEPPSS VAAAHRIGVL LINLGTPDAP TPRAVRRYLA EFLSDPRVVE IPQAIWQVLL 70 80 90 100 110 120 RTVILPLRGR ASAKKYAAVW MPEGSPLRVY TERQTEGVRH LLAANDYQVQ VDYAMRYGSP 130 140 150 160 170 180 NIAQALAQFK RAGVERVLLM PMYPQYSAST TATAFDAAFA ALTRMRNQPE VRTVRHYADH 190 200 210 220 230 240 PAYIHALAEQ VRHYWAQHGR PDFAAGDKLV LSFHGVPKRT LDLGDPYHDQ CQQTGALLMA 250 260 270 280 290 300 ALGLSTLECR VTFQSRFGKA EWLQPYTAPT LRELGEAGVR RADVFCPGFT ADCLETIEEI 310 320 330 340 350 GMEVRDEFLA GGGQAFHRIP CLNGASAWIG ALGEIVAENL QGWPAKAAQP ETVS

References

[1]

"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000614 Genomic DNA. Translation: ABO53719.1.
RefSeq	YP_001118554.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4JBR6.
Genome annotation databases
GeneID	4952402.
GenomeReviews	Gene locus Bcep1808_0707 in contig CP000614_GR.
KEGG	bvi:Bcep1808_0707.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TIEEIGM.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_BURVG

Accession

Primary (citable) accession number: A4JBR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)