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Protein

Adenylosuccinate lyase

Gene

Bcep1808_0632

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (Bcep1808_0632)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Bcep1808_0632)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-639-MONOMER
UniPathwayiUPA00074; UER00132
UPA00075; UER00336

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Ordered Locus Names:Bcep1808_0632Imported
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))Imported
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi269482.Bcep1808_0632

Structurei

3D structure databases

ProteinModelPortaliA4JBJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 318Lyase_1InterPro annotationAdd BLAST299
Domaini337 – 451ASL_CInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTF Bacteria
COG0015 LUCA
HOGENOMiHOG000252916
KOiK01756
OMAiTQVNPCD
OrthoDBiPOG091H01RB

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR004769 Pur_lyase
IPR013539 PurB_C
PfamiView protein in Pfam
PF08328 ASL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00928 purB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A4JBJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTRPDTLF ALTALSPIDG RYASKTEALR DWLSEAAFMR HRVTVEVHWL
60 70 80 90 100
IALSRAGFAE IPRFSDASEQ FLLQLAERFT AHDAARIKDI ERVTNHDVKA
110 120 130 140 150
VEYWLKESVK GQAELEKASE FIHFACTSED INNTSHGMML AGAREHVIVP
160 170 180 190 200
ALRTVHQRLV ALAHALADQP MLSRTHGQPA SPTTLGKELA NVAARLGRAI
210 220 230 240 250
ARIEKVEILG KMNGAVGNFN AHLSAYPEFD WEAFSRDVIE NRLKLTFNPY
260 270 280 290 300
TIQIEPHDYM AELFDAVARA NTILLDLDRD VWGYISVGYF KQKTKAGEIG
310 320 330 340 350
SSTMPHKVNP IDFENSEGNL GLANATLRHL ADKLPVSRWQ RDLTDSTVLR
360 370 380 390 400
NMGVALGYSL LAYDSLIRGL DKLEVNPQRL HDDLDNCWEV LAEPVQTVMR
410 420 430 440 450
RYGIENPYEQ LKELTRGKGI TREALQEFVA TLAIPQDAKD RLLAMTPASY
460
IGKAVELAKR IA
Length:462
Mass (Da):51,768
Last modified:May 1, 2007 - v1
Checksum:iA3FE6A95C45A6FCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000614 Genomic DNA Translation: ABO53644.1

Genome annotation databases

EnsemblBacteriaiABO53644; ABO53644; Bcep1808_0632
KEGGibvi:Bcep1808_0632

Similar proteinsi

Entry informationi

Entry nameiA4JBJ1_BURVG
AccessioniPrimary (citable) accession number: A4JBJ1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health