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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathway:icoenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei140 – 1401ADPCombined sources
Binding sitei144 – 1441ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPUniRule annotation
Nucleotide bindingi11 – 166ADPCombined sources
Nucleotide bindingi175 – 1806ADPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Coenzyme A biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-570-MONOMER.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:Bcep1808_0550Imported
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))Imported
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002287 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi269482.Bcep1808_0550.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1UX-ray2.05A/B1-202[»]
4I1VX-ray2.60A/B1-202[»]
ProteinModelPortaliA4JBA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 201199DPCKUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation
Contains DPCK (dephospho-CoA kinase) domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0237.
HOGENOMiHOG000020769.
KOiK00859.
OMAiGGKKRYP.
OrthoDBiEOG6HTP3H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4JBA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAIGLTGGI GSGKTTVADL FAARGASLVD TDLIAHRITA PAGLAMPAIE
60 70 80 90 100
QTFGPAFVAA DGSLDRARMR ALIFSDEDAR RRLEAITHPL IRAETEREAR
110 120 130 140 150
DAQGPYVIFV VPLLVESRNW KARCDRVLVV DCPVDTQIAR VMQRNGFTRE
160 170 180 190 200
QVEAIIARQA TREARLAAAD DVIVNDAATP DALAVQVDAL HQRYLAFAAA

KH
Length:202
Mass (Da):21,889
Last modified:May 1, 2007 - v1
Checksum:iEE9E620DAE950D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000614 Genomic DNA. Translation: ABO53562.1.
RefSeqiWP_011883191.1. NC_009256.1.

Genome annotation databases

EnsemblBacteriaiABO53562; ABO53562; Bcep1808_0550.
KEGGibvi:Bcep1808_0550.
PATRICi19319514. VBIBurVie89221_4749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000614 Genomic DNA. Translation: ABO53562.1.
RefSeqiWP_011883191.1. NC_009256.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1UX-ray2.05A/B1-202[»]
4I1VX-ray2.60A/B1-202[»]
ProteinModelPortaliA4JBA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269482.Bcep1808_0550.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO53562; ABO53562; Bcep1808_0550.
KEGGibvi:Bcep1808_0550.
PATRICi19319514. VBIBurVie89221_4749.

Phylogenomic databases

eggNOGiCOG0237.
HOGENOMiHOG000020769.
KOiK00859.
OMAiGGKKRYP.
OrthoDBiEOG6HTP3H.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.
BioCyciBVIE269482:GJNA-570-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Tiedje J., Richardson P.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G4 / LMG 22486Imported.
  2. "Apo crystal structure of a dephospho-CoA kinase from Burkholderia vietnamiensis."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Edwards T.E., Abendroth J.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
  3. "Crystal structure of a dephospho-CoA kinase from Burkholderia vietnamiensis bound to ADP."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Edwards T.E., Clifton M.C., Sankaran B.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ADP.

Entry informationi

Entry nameiA4JBA9_BURVG
AccessioniPrimary (citable) accession number: A4JBA9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 22, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.