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A4JBA9

- A4JBA9_BURVG

UniProt

A4JBA9 - A4JBA9_BURVG

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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 271Sulfate 2
Binding sitei37 – 371Sulfate 2
Binding sitei44 – 441Chloride; via amide nitrogen
Binding sitei68 – 681Sulfate 3
Binding sitei88 – 881Sulfate 5
Binding sitei92 – 921Sulfate 5
Binding sitei100 – 1001Sulfate 6
Binding sitei103 – 1031Sulfate 2; via amide nitrogen
Binding sitei126 – 1261Sulfate 7
Binding sitei140 – 1401ADPImported
Binding sitei140 – 1401Sulfate 8
Binding sitei144 – 1441ADPImported
Binding sitei144 – 1441Sulfate 1
Binding sitei176 – 1761Sulfate 8; via carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPUniRule annotation
Nucleotide bindingi11 – 166ADPImported
Nucleotide bindingi175 – 1806ADPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. dephospho-CoA kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Coenzyme A biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBVIE269482:GJNA-570-MONOMER.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:Bcep1808_0550Imported
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))Imported
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002287: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi269482.Bcep1808_0550.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1UX-ray2.05A/B1-202[»]
4I1VX-ray2.60A/B1-202[»]
ProteinModelPortaliA4JBA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 201199DPCKUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni11 – 144Sulfate 1 binding
Regioni80 – 812Sulfate 4 binding
Regioni117 – 1204Sulfate 5 binding

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation
Contains DPCK (dephospho-CoA kinase) domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0237.
HOGENOMiHOG000020769.
KOiK00859.
OMAiRERVFNH.
OrthoDBiEOG6HTP3H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4JBA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYAIGLTGGI GSGKTTVADL FAARGASLVD TDLIAHRITA PAGLAMPAIE
60 70 80 90 100
QTFGPAFVAA DGSLDRARMR ALIFSDEDAR RRLEAITHPL IRAETEREAR
110 120 130 140 150
DAQGPYVIFV VPLLVESRNW KARCDRVLVV DCPVDTQIAR VMQRNGFTRE
160 170 180 190 200
QVEAIIARQA TREARLAAAD DVIVNDAATP DALAVQVDAL HQRYLAFAAA

KH
Length:202
Mass (Da):21,889
Last modified:May 1, 2007 - v1
Checksum:iEE9E620DAE950D0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000614 Genomic DNA. Translation: ABO53562.1.
RefSeqiWP_011883191.1. NC_009256.1.
YP_001118397.1. NC_009256.1.

Genome annotation databases

EnsemblBacteriaiABO53562; ABO53562; Bcep1808_0550.
GeneIDi4952243.
KEGGibvi:Bcep1808_0550.
PATRICi19319514. VBIBurVie89221_4749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000614 Genomic DNA. Translation: ABO53562.1 .
RefSeqi WP_011883191.1. NC_009256.1.
YP_001118397.1. NC_009256.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I1U X-ray 2.05 A/B 1-202 [» ]
4I1V X-ray 2.60 A/B 1-202 [» ]
ProteinModelPortali A4JBA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269482.Bcep1808_0550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO53562 ; ABO53562 ; Bcep1808_0550 .
GeneIDi 4952243.
KEGGi bvi:Bcep1808_0550.
PATRICi 19319514. VBIBurVie89221_4749.

Phylogenomic databases

eggNOGi COG0237.
HOGENOMi HOG000020769.
KOi K00859.
OMAi RERVFNH.
OrthoDBi EOG6HTP3H.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00356 .
BioCyci BVIE269482:GJNA-570-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00376. Dephospho_CoA_kinase.
InterProi IPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01121. CoaE. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00152. TIGR00152. 1 hit.
PROSITEi PS51219. DPCK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Tiedje J., Richardson P.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G4 / LMG 22486Imported.
  2. "Apo crystal structure of a dephospho-CoA kinase from Burkholderia vietnamiensis."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Edwards T.E., Abendroth J.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
  3. "Crystal structure of a dephospho-CoA kinase from Burkholderia vietnamiensis bound to ADP."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Edwards T.E., Clifton M.C., Sankaran B.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ADP.

Entry informationi

Entry nameiA4JBA9_BURVG
AccessioniPrimary (citable) accession number: A4JBA9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3