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A4JBA9

- A4JBA9_BURVG

UniProt

A4JBA9 - A4JBA9_BURVG

Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

    Catalytic activityi

    ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei27 – 271Sulfate 2
    Binding sitei37 – 371Sulfate 2
    Binding sitei44 – 441Chloride; via amide nitrogen
    Binding sitei68 – 681Sulfate 3
    Binding sitei88 – 881Sulfate 5
    Binding sitei92 – 921Sulfate 5
    Binding sitei100 – 1001Sulfate 6
    Binding sitei103 – 1031Sulfate 2; via amide nitrogen
    Binding sitei126 – 1261Sulfate 7
    Binding sitei140 – 1401ADPImported
    Binding sitei140 – 1401Sulfate 8
    Binding sitei144 – 1441ADPImported
    Binding sitei144 – 1441Sulfate 1
    Binding sitei176 – 1761Sulfate 8; via carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 158ATPUniRule annotation
    Nucleotide bindingi11 – 166ADPImported
    Nucleotide bindingi175 – 1806ADPImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. dephospho-CoA kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBVIE269482:GJNA-570-MONOMER.
    UniPathwayiUPA00241; UER00356.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
    Alternative name(s):
    Dephosphocoenzyme A kinaseUniRule annotation
    Gene namesi
    Name:coaEUniRule annotation
    Ordered Locus Names:Bcep1808_0550Imported
    OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))Imported
    Taxonomic identifieri269482 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002287: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi269482.Bcep1808_0550.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I1UX-ray2.05A/B1-202[»]
    4I1VX-ray2.60A/B1-202[»]
    ProteinModelPortaliA4JBA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 201199DPCKUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni11 – 144Sulfate 1 binding
    Regioni80 – 812Sulfate 4 binding
    Regioni117 – 1204Sulfate 5 binding

    Sequence similaritiesi

    Belongs to the CoaE family.UniRule annotation
    Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation
    Contains DPCK (dephospho-CoA kinase) domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0237.
    HOGENOMiHOG000020769.
    KOiK00859.
    OMAiRERVFNH.
    OrthoDBiEOG6HTP3H.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00376. Dephospho_CoA_kinase.
    InterProiIPR001977. Depp_CoAkinase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01121. CoaE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
    PROSITEiPS51219. DPCK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4JBA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYAIGLTGGI GSGKTTVADL FAARGASLVD TDLIAHRITA PAGLAMPAIE    50
    QTFGPAFVAA DGSLDRARMR ALIFSDEDAR RRLEAITHPL IRAETEREAR 100
    DAQGPYVIFV VPLLVESRNW KARCDRVLVV DCPVDTQIAR VMQRNGFTRE 150
    QVEAIIARQA TREARLAAAD DVIVNDAATP DALAVQVDAL HQRYLAFAAA 200
    KH 202
    Length:202
    Mass (Da):21,889
    Last modified:May 1, 2007 - v1
    Checksum:iEE9E620DAE950D0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO53562.1.
    RefSeqiWP_011883191.1. NC_009256.1.
    YP_001118397.1. NC_009256.1.

    Genome annotation databases

    EnsemblBacteriaiABO53562; ABO53562; Bcep1808_0550.
    GeneIDi4952243.
    KEGGibvi:Bcep1808_0550.
    PATRICi19319514. VBIBurVie89221_4749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO53562.1 .
    RefSeqi WP_011883191.1. NC_009256.1.
    YP_001118397.1. NC_009256.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I1U X-ray 2.05 A/B 1-202 [» ]
    4I1V X-ray 2.60 A/B 1-202 [» ]
    ProteinModelPortali A4JBA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269482.Bcep1808_0550.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO53562 ; ABO53562 ; Bcep1808_0550 .
    GeneIDi 4952243.
    KEGGi bvi:Bcep1808_0550.
    PATRICi 19319514. VBIBurVie89221_4749.

    Phylogenomic databases

    eggNOGi COG0237.
    HOGENOMi HOG000020769.
    KOi K00859.
    OMAi RERVFNH.
    OrthoDBi EOG6HTP3H.

    Enzyme and pathway databases

    UniPathwayi UPA00241 ; UER00356 .
    BioCyci BVIE269482:GJNA-570-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00376. Dephospho_CoA_kinase.
    InterProi IPR001977. Depp_CoAkinase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01121. CoaE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00152. TIGR00152. 1 hit.
    PROSITEi PS51219. DPCK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Tiedje J., Richardson P.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G4 / LMG 22486Imported.
    2. "Apo crystal structure of a dephospho-CoA kinase from Burkholderia vietnamiensis."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Edwards T.E., Abendroth J.
      Submitted (NOV-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
    3. "Crystal structure of a dephospho-CoA kinase from Burkholderia vietnamiensis bound to ADP."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Edwards T.E., Clifton M.C., Sankaran B.
      Submitted (NOV-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ADP.

    Entry informationi

    Entry nameiA4JBA9_BURVG
    AccessioniPrimary (citable) accession number: A4JBA9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3