A4JAX1 (HIS2_BURVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase
Short name=PRA-PH
EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	Bcep1808_0412

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 121	121	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_1000063332

Sequences

	Sequence		Length	Mass (Da)
	A4JAX1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: B9E6AAF8435F8C48	FASTA	121	13,244
	10 20 30 40 50 60 MTQSTEDTLL RLAAVIDSRK GGDPEQSYVS RLFHKGDDAV LKKIGEEATE VVLAAKDVRQ 70 80 90 100 110 120 GGAPTALVGE VADLWFHCLV MLSHFDLSPA DVIAELERRE GLSGIEEKAL RKRREREANG G

References

[1]

"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G4 / LMG 22486.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000614 Genomic DNA. Translation: ABO53424.1.
RefSeq	YP_001118259.1. NC_009256.1.
3D structure databases
ProteinModelPortal	A4JAX1.
ModBase	Search...
Protein-protein interaction databases
STRING	A4JAX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4952099.
GenomeReviews	Gene locus Bcep1808_0412 in contig CP000614_GR.
KEGG	bvi:Bcep1808_0412.
PATRIC	19319222. VBIBurVie89221_4609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0140.
HOGENOM	HBG646527.
OMA	ETVMAAK.
ProtClustDB	PRK00400.
Enzyme and pathway databases
BioCyc	BVIE269482:BCEP1808_0412-MONOMER.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. [Graphical view]
KO	K01523.
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_BURVG

Accession

Primary (citable) accession number: A4JAX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program