Reviewed, UniProtKB/Swiss-Prot A4JAT5 (AROB_BURVG)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Bcep1808_0375

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094480

Sequences

	Sequence		Length	Mass (Da)
	A4JAT5-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: F3269DE22C8E8748	FASTA	359	37,897
	10 20 30 40 50 60 MITVNVDLGD RAYPIHIGAG LIGRTELFAP HINGSSVTIV TNTTVDPLYG DALRAALAPL 70 80 90 100 110 120 GKRVSTVVLP DGEAYKNWET LNLIFDGLLT ERADRKTTLI ALGGGVIGDM TGFAAACYMR 130 140 150 160 170 180 GVPFIQVPTT LLSQVDSSVG GKTGINHPLG KNMIGAFYQP QAVVADIGAL ATLPDRELAA 190 200 210 220 230 240 GIAEVIKTGA IADAEFFDWI EANVDALNRR EPAVLVHAVK RSCEIKASVV AADEREGGLR 250 260 270 280 290 300 AILNFGHTFG HAIEAGLGYG EWLHGEAVGC GMVMAGDLSV RLGLLDEASR QRLDAVIAAA 310 320 330 340 350 RLPVSGPALG EARYMDLMRV DKKAEAGAIK FILLKRFGDT LIAPAPDEAV FATLAKTTR

References

[1]

"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000614 Genomic DNA. Translation: ABO53388.1.
RefSeq	YP_001118223.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4JAT5.
Genome annotation databases
GeneID	4952062.
GenomeReviews	Gene locus Bcep1808_0375 in contig CP000614_GR.
KEGG	bvi:Bcep1808_0375.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EDYLPHM.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BURVG

Accession

Primary (citable) accession number: A4JAT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 1, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)