A4JA71 (GCST_BURVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Bcep1808_0151

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Aminomethyltransferase HAMAP MF_00259		PRO_1000047653

Sequences

	Sequence		Length	Mass (Da)
	A4JA71 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 1F7BBE961EECB4C9	FASTA	372	40,120
	10 20 30 40 50 60 MTALNHTPLN AAHRALNARM VDFGGWDMPV NYGSQIEEHE AVRTDAGMFD VSHMCVVDFT 70 80 90 100 110 120 GSRVRAFFEH ALANNVGKLK TPGKALYSCL LNPQGGVIDD LIVYYFTEDF FRVVVNAGTA 130 140 150 160 170 180 EKDIAWFNQL NEQGGYGLTI APRRDFAIVA VQGPNAREKV WATVPAARAA TSELKPFNAA 190 200 210 220 230 240 QVAGTPFGDL TVARTGYTGE DGFEVIVPAV HVVALWNALQ QNGVRPCGLG ARDTLRLEAG 250 260 270 280 290 300 MNLYGQDMDE TVSPLDAGLA WTVDLSAPRE FVGRPALERD GTRAAFVGLI LQKENGKAGG 310 320 330 340 350 360 VLRAHQKVVT PHGEGEITSG TFSPSMQESI AFARVPAAVQ LGDIVHVQIR DKQLPARVVK 370 LPFVRNGKVL AA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G4 / LMG 22486.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000614 Genomic DNA. Translation: ABO53174.1.
RefSeq	YP_001118009.1. NC_009256.1.
3D structure databases
ProteinModelPortal	A4JA71.
SMR	A4JA71. Positions 6-371.
ModBase	Search...
Protein-protein interaction databases
STRING	A4JA71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4951827.
GenomeReviews	Gene locus Bcep1808_0151 in contig CP000614_GR.
KEGG	bvi:Bcep1808_0151.
PATRIC	19318705. VBIBurVie89221_4362.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	BVIE269482:BCEP1808_0151-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BURVG

Accession

Primary (citable) accession number: A4JA71

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program