Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4JA69

- GCSP_BURVG

UniProt

A4JA69 - GCSP_BURVG

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBVIE269482:GJNA-152-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Bcep1808_0149
    OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
    Taxonomic identifieri269482 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002287: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 975975Glycine dehydrogenase (decarboxylating)PRO_1000045577Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei723 – 7231N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi269482.Bcep1808_0149.

    Structurei

    3D structure databases

    ProteinModelPortaliA4JA69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4JA69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKHEHPDRLM NRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFASR    50
    AALIDAVIPA SIRRAEALPL GPFAQPKSEA EALAALRALA DKNQVFRSYI 100
    GQGYYDSHTP AVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMVV 150
    DLTGLAISNA SLLDEATAAA EAMTLLQRTG KPKSNVFYVA DDVLPQTLEV 200
    VRTRALPIGI EVKTGPAAEA AQAGAFGVLL QYPGVNGDVR DYRALTDAIH 250
    AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPM GFGGPHAAYM 300
    AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA 350
    QALLAIMASM YAVYHGPHGL KTIALRVNRI AALLAAGVKQ LGFTTVNDTF 400
    FDTLTIDAGA RTAQLHAFAN AKRINLRRVS DTQVGVSVDE TTTRDDLADL 450
    LAVFAQAAGG TAPDVDALDA GLPGVAALPA GLERTSAYLT HHVFNRHHSE 500
    TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV TWPEFGRIHP 550
    FAPSEQTAGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLVIHA 600
    YHASRGEAHR DVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIADL 650
    KAKAEQHAND LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM 700
    NAMVGLTAPG QFGGDVSHLN LHKTFCIPHG GGGPGVGPVA VGPHLAKFLP 750
    NQRSTGYARG EEGIGAVSAA PYGSASILPI SWMYIAMMGA KNLTAATETA 800
    ILNANYIAKR LAPHYPVLYS GPGGLVAHEC ILDLRPIKET SGITVDDVAK 850
    RLMDYGFHAP TMSFPVPGTL MVEPTESESQ EELDRFIAAM IAIREEIRAV 900
    EEGRADREDN PLRHAPHTAA VVTANEWPHA YSREQAAYPV ASLVTNKYWP 950
    PVGRADNAYG DRNLFCSCVP MSEYA 975
    Length:975
    Mass (Da):104,325
    Last modified:May 1, 2007 - v1
    Checksum:i78C87F78CC106869
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO53172.1.
    RefSeqiWP_011882850.1. NC_009256.1.
    YP_001118007.1. NC_009256.1.

    Genome annotation databases

    EnsemblBacteriaiABO53172; ABO53172; Bcep1808_0149.
    GeneIDi4951825.
    KEGGibvi:Bcep1808_0149.
    PATRICi19318701. VBIBurVie89221_4360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000614 Genomic DNA. Translation: ABO53172.1 .
    RefSeqi WP_011882850.1. NC_009256.1.
    YP_001118007.1. NC_009256.1.

    3D structure databases

    ProteinModelPortali A4JA69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269482.Bcep1808_0149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO53172 ; ABO53172 ; Bcep1808_0149 .
    GeneIDi 4951825.
    KEGGi bvi:Bcep1808_0149.
    PATRICi 19318701. VBIBurVie89221_4360.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BVIE269482:GJNA-152-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Tiedje J., Richardson P.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G4 / LMG 22486.

    Entry informationi

    Entry nameiGCSP_BURVG
    AccessioniPrimary (citable) accession number: A4JA69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3