A4JA40 (DCUP_BURVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Bcep1808_0120

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) [Complete proteome] [HAMAP]

Taxonomic identifier

269482 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.
Sequence caution	The sequence ABO53143.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000325631
Regions
	Region	28 – 32	5	Substrate binding By similarity
Sites
	Binding site	78	1	Substrate By similarity
	Binding site	160	1	Substrate By similarity
	Binding site	215	1	Substrate By similarity
	Binding site	333	1	Substrate By similarity
	Site	78	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4JA40 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 4175A316A5C3167A	FASTA	364	39,543
	10 20 30 40 50 60 MAHTLLNDTF LRALLREPTD YTPIWLMRQA GRYLPEYNAT RARAGSFLGL AKNPDYATEV 70 80 90 100 110 120 TLQPLDRFPL DAAILFSDIL TIPDAMGLGL DFQAGEGPKF AHPVRTEADV AKLAVPDIDE 130 140 150 160 170 180 TLGYVTGAVR EIRRALTDGQ GRQRVPLIGF SGSPWTLACY MVEGGGSDDF RTVKSMAYSR 190 200 210 220 230 240 PDLMHRILDV NAQAVAAYLN AQIEAGAQAV MIFDTWGGAL ADGAYQRFSL DYIRRVVAQL 250 260 270 280 290 300 KREHDGERVP VITFTKGGGL WLEEIAATGV DAVGLDWTVN LGAARERVAG RVALQGNLDP 310 320 330 340 350 360 TILFAPPAAV REQARAVLDS YGNHPGHVFN LGHGISQFTS PDHVAELVDE VHGYSRKLRS GAAG

References

[1]

"Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G4 / LMG 22486.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000614 Genomic DNA. Translation: ABO53143.1. Different initiation.
RefSeq	YP_001117978.1. NC_009256.1.
3D structure databases
ProteinModelPortal	A4JA40.
ModBase	Search...
Protein-protein interaction databases
STRING	A4JA40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4951796.
GenomeReviews	Gene locus Bcep1808_0120 in contig CP000614_GR.
KEGG	bvi:Bcep1808_0120.
PATRIC	19318639. VBIBurVie89221_4329.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0407.
HOGENOM	HBG628392.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	BVIE269482:BCEP1808_0120-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BURVG

Accession

Primary (citable) accession number: A4JA40

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	December 14, 2011
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program