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Protein

Thioredoxin reductase

Gene

Dred_2670

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Ligandi

FADUniRule annotationSAAS annotation, Flavoprotein, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDRED349161:GHP6-2749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductaseUniRule annotation (EC:1.8.1.9UniRule annotation)
Gene namesi
Ordered Locus Names:Dred_2670Imported
OrganismiDesulfotomaculum reducens (strain MI-1)Imported
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000001556 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi349161.Dred_2670.

Structurei

3D structure databases

ProteinModelPortaliA4J7X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072911.
KOiK00384.
OMAiDIRNTPY.
OrthoDBiEOG65XN2W.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4J7X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTTHDIII IGAGPAGLAA GIYGARAKLR TLIIEKGAIG GMASNTREIV
60 70 80 90 100
NYPGFKQTSG TALTKEMAEH AKEMGTEIIK GEVKTVDLSG EIKRVVTRKK
110 120 130 140 150
QEFTARAVIL ATGTLPRVLG IPGEKELRGN GVAYCATCDA EFFEGQHVVV
160 170 180 190 200
VGSGDQAIEE GMFIAKFANQ VTVIVLHDEG KLDCNRLSAE KALHHPKLKF
210 220 230 240 250
VWNSTLTAVQ GDEEVTGVQV KNIKTGEMSE IPCQGVFFFV GMIPATHFLK
260 270 280 290 300
GQVELDDRGY VMVNDLLETS VEGVFAAGDL RPKYLRQVVT ATADGAAAVV
310 320 330 340 350
AAERYLQEKE NLRTTVLEAE KPVILAFWSP EDQASLQAVS RVEKVVSELP
360 370 380 390 400
NEYLFVKTDV TRQRMLAKKY QVTTLPRVFV LNKGEVVQTI DTDAEVDDIK
410
EILKALIQQA
Length:410
Mass (Da):44,690
Last modified:May 1, 2007 - v1
Checksum:iAF823B4A4CD4660A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO51176.1.
RefSeqiWP_011878973.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO51176; ABO51176; Dred_2670.
KEGGidrm:Dred_2670.
PATRICi21731753. VBIDesRed82656_2923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO51176.1.
RefSeqiWP_011878973.1. NC_009253.1.

3D structure databases

ProteinModelPortaliA4J7X3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349161.Dred_2670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO51176; ABO51176; Dred_2670.
KEGGidrm:Dred_2670.
PATRICi21731753. VBIDesRed82656_2923.

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072911.
KOiK00384.
OMAiDIRNTPY.
OrthoDBiEOG65XN2W.

Enzyme and pathway databases

BioCyciDRED349161:GHP6-2749-MONOMER.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MI-1Imported.

Entry informationi

Entry nameiA4J7X3_DESRM
AccessioniPrimary (citable) accession number: A4J7X3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.