Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4J7X3

- A4J7X3_DESRM

UniProt

A4J7X3 - A4J7X3_DESRM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thioredoxin reductase

Gene

Dred_2670

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.UniRule annotation

Cofactori

Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. thioredoxin-disulfide reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. removal of superoxide radicals Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Ligandi

FADUniRule annotationSAAS annotation, Flavoprotein, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDRED349161:GHP6-2749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductaseUniRule annotation (EC:1.8.1.9UniRule annotation)
Gene namesi
Ordered Locus Names:Dred_2670Imported
OrganismiDesulfotomaculum reducens (strain MI-1)Imported
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000001556: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi349161.Dred_2670.

Structurei

3D structure databases

ProteinModelPortaliA4J7X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072911.
KOiK00384.
OMAiVLDQGKE.
OrthoDBiEOG65XN2W.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
PR00469. PNDRDTASEII.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4J7X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNTTHDIII IGAGPAGLAA GIYGARAKLR TLIIEKGAIG GMASNTREIV
60 70 80 90 100
NYPGFKQTSG TALTKEMAEH AKEMGTEIIK GEVKTVDLSG EIKRVVTRKK
110 120 130 140 150
QEFTARAVIL ATGTLPRVLG IPGEKELRGN GVAYCATCDA EFFEGQHVVV
160 170 180 190 200
VGSGDQAIEE GMFIAKFANQ VTVIVLHDEG KLDCNRLSAE KALHHPKLKF
210 220 230 240 250
VWNSTLTAVQ GDEEVTGVQV KNIKTGEMSE IPCQGVFFFV GMIPATHFLK
260 270 280 290 300
GQVELDDRGY VMVNDLLETS VEGVFAAGDL RPKYLRQVVT ATADGAAAVV
310 320 330 340 350
AAERYLQEKE NLRTTVLEAE KPVILAFWSP EDQASLQAVS RVEKVVSELP
360 370 380 390 400
NEYLFVKTDV TRQRMLAKKY QVTTLPRVFV LNKGEVVQTI DTDAEVDDIK
410
EILKALIQQA
Length:410
Mass (Da):44,690
Last modified:May 1, 2007 - v1
Checksum:iAF823B4A4CD4660A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000612 Genomic DNA. Translation: ABO51176.1.
RefSeqiWP_011878973.1. NC_009253.1.
YP_001114001.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO51176; ABO51176; Dred_2670.
GeneIDi4958660.
KEGGidrm:Dred_2670.
PATRICi21731753. VBIDesRed82656_2923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000612 Genomic DNA. Translation: ABO51176.1 .
RefSeqi WP_011878973.1. NC_009253.1.
YP_001114001.1. NC_009253.1.

3D structure databases

ProteinModelPortali A4J7X3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349161.Dred_2670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO51176 ; ABO51176 ; Dred_2670 .
GeneIDi 4958660.
KEGGi drm:Dred_2670.
PATRICi 21731753. VBIDesRed82656_2923.

Phylogenomic databases

eggNOGi COG0492.
HOGENOMi HOG000072911.
KOi K00384.
OMAi VLDQGKE.
OrthoDBi EOG65XN2W.

Enzyme and pathway databases

BioCyci DRED349161:GHP6-2749-MONOMER.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
PR00469. PNDRDTASEII.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01292. TRX_reduct. 1 hit.
PROSITEi PS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MI-1Imported.

Entry informationi

Entry nameiA4J7X3_DESRM
AccessioniPrimary (citable) accession number: A4J7X3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3