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A4J7X3

- A4J7X3_DESRM

UniProt

A4J7X3 - A4J7X3_DESRM

Protein

Thioredoxin reductase

Gene

Dred_2670

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.UniRule annotation

    Cofactori

    Binds 1 FAD per subunit.UniRule annotation

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. thioredoxin-disulfide reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. removal of superoxide radicals Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    FADUniRule annotationSAAS annotation, Flavoprotein, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciDRED349161:GHP6-2749-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin reductaseUniRule annotation (EC:1.8.1.9UniRule annotation)
    Gene namesi
    Ordered Locus Names:Dred_2670Imported
    OrganismiDesulfotomaculum reducens (strain MI-1)Imported
    Taxonomic identifieri349161 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000001556: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi349161.Dred_2670.

    Structurei

    3D structure databases

    ProteinModelPortaliA4J7X3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

    Keywords - Domaini

    Redox-active centerUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0492.
    HOGENOMiHOG000072911.
    KOiK00384.
    OMAiVLDQGKE.
    OrthoDBiEOG65XN2W.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    IPR005982. Thioredox_Rdtase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    PR00469. PNDRDTASEII.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
    PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4J7X3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNTTHDIII IGAGPAGLAA GIYGARAKLR TLIIEKGAIG GMASNTREIV    50
    NYPGFKQTSG TALTKEMAEH AKEMGTEIIK GEVKTVDLSG EIKRVVTRKK 100
    QEFTARAVIL ATGTLPRVLG IPGEKELRGN GVAYCATCDA EFFEGQHVVV 150
    VGSGDQAIEE GMFIAKFANQ VTVIVLHDEG KLDCNRLSAE KALHHPKLKF 200
    VWNSTLTAVQ GDEEVTGVQV KNIKTGEMSE IPCQGVFFFV GMIPATHFLK 250
    GQVELDDRGY VMVNDLLETS VEGVFAAGDL RPKYLRQVVT ATADGAAAVV 300
    AAERYLQEKE NLRTTVLEAE KPVILAFWSP EDQASLQAVS RVEKVVSELP 350
    NEYLFVKTDV TRQRMLAKKY QVTTLPRVFV LNKGEVVQTI DTDAEVDDIK 400
    EILKALIQQA 410
    Length:410
    Mass (Da):44,690
    Last modified:May 1, 2007 - v1
    Checksum:iAF823B4A4CD4660A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO51176.1.
    RefSeqiWP_011878973.1. NC_009253.1.
    YP_001114001.1. NC_009253.1.

    Genome annotation databases

    EnsemblBacteriaiABO51176; ABO51176; Dred_2670.
    GeneIDi4958660.
    KEGGidrm:Dred_2670.
    PATRICi21731753. VBIDesRed82656_2923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO51176.1 .
    RefSeqi WP_011878973.1. NC_009253.1.
    YP_001114001.1. NC_009253.1.

    3D structure databases

    ProteinModelPortali A4J7X3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349161.Dred_2670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO51176 ; ABO51176 ; Dred_2670 .
    GeneIDi 4958660.
    KEGGi drm:Dred_2670.
    PATRICi 21731753. VBIDesRed82656_2923.

    Phylogenomic databases

    eggNOGi COG0492.
    HOGENOMi HOG000072911.
    KOi K00384.
    OMAi VLDQGKE.
    OrthoDBi EOG65XN2W.

    Enzyme and pathway databases

    BioCyci DRED349161:GHP6-2749-MONOMER.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    IPR005982. Thioredox_Rdtase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    PR00469. PNDRDTASEII.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01292. TRX_reduct. 1 hit.
    PROSITEi PS00573. PYRIDINE_REDOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MI-1Imported.

    Entry informationi

    Entry nameiA4J7X3_DESRM
    AccessioniPrimary (citable) accession number: A4J7X3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3