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Protein

Thioredoxin reductase

Gene

Dred_2670

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDRED349161:G1G8H-2883-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductaseUniRule annotation (EC:1.8.1.9UniRule annotation)
Gene namesi
Ordered Locus Names:Dred_2670Imported
OrganismiDesulfotomaculum reducens (strain MI-1)Imported
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
Proteomesi
  • UP000001556 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi349161.Dred_2670

Structurei

3D structure databases

ProteinModelPortaliA4J7X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 295FAD/NAD-binding_domInterPro annotationAdd BLAST290
Domaini308 – 404ThioredoxinInterPro annotationAdd BLAST97

Sequence similaritiesi

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3M Bacteria
COG0492 LUCA
HOGENOMiHOG000072911
KOiK00384
OMAiHEMENYP
OrthoDBiPOG091H02HU

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR005982 Thioredox_Rdtase
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF00085 Thioredoxin, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01292 TRX_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4J7X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTTHDIII IGAGPAGLAA GIYGARAKLR TLIIEKGAIG GMASNTREIV
60 70 80 90 100
NYPGFKQTSG TALTKEMAEH AKEMGTEIIK GEVKTVDLSG EIKRVVTRKK
110 120 130 140 150
QEFTARAVIL ATGTLPRVLG IPGEKELRGN GVAYCATCDA EFFEGQHVVV
160 170 180 190 200
VGSGDQAIEE GMFIAKFANQ VTVIVLHDEG KLDCNRLSAE KALHHPKLKF
210 220 230 240 250
VWNSTLTAVQ GDEEVTGVQV KNIKTGEMSE IPCQGVFFFV GMIPATHFLK
260 270 280 290 300
GQVELDDRGY VMVNDLLETS VEGVFAAGDL RPKYLRQVVT ATADGAAAVV
310 320 330 340 350
AAERYLQEKE NLRTTVLEAE KPVILAFWSP EDQASLQAVS RVEKVVSELP
360 370 380 390 400
NEYLFVKTDV TRQRMLAKKY QVTTLPRVFV LNKGEVVQTI DTDAEVDDIK
410
EILKALIQQA
Length:410
Mass (Da):44,690
Last modified:May 1, 2007 - v1
Checksum:iAF823B4A4CD4660A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA Translation: ABO51176.1
RefSeqiWP_011878973.1, NC_009253.1

Genome annotation databases

EnsemblBacteriaiABO51176; ABO51176; Dred_2670
KEGGidrm:Dred_2670

Similar proteinsi

Entry informationi

Entry nameiA4J7X3_DESRM
AccessioniPrimary (citable) accession number: A4J7X3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health