Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4J7H2

- SYL_DESRM

UniProt

A4J7H2 - SYL_DESRM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDRED349161:GHP6-2586-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Dred_2515
    OrganismiDesulfotomaculum reducens (strain MI-1)
    Taxonomic identifieri349161 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000001556: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 827827Leucine--tRNA ligasePRO_0000334750Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349161.Dred_2515.

    Structurei

    3D structure databases

    ProteinModelPortaliA4J7H2.
    SMRiA4J7H2. Positions 3-762.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4J7H2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEHYDFKEI EKKWQEDWNK ENTYQVPDFS ERPKYYCLEM FPYPSGKLHM    50
    GHVRNYSIGD VVARFKTMQG YDVLHPMGWD AFGLPAENAA IKHGIAPATW 100
    TWDNIAHMRS QLKQLGLSYD WNREVATCHT EYYKWGQWLF LQLYKKGLCY 150
    KKHARVNWCP DCATVLANEQ VVDGACERCS AVVEQKELDQ WFFRITEYAQ 200
    RLLNDLKLLK GWPDKVKIMQ ENWIGRSEGA ELTFQVEGSD ESITVFTTRP 250
    DTVYGVSYMV LAPEHPLVAK LIAGRPQEAE VIGFVNRVNK LTELDRTSSD 300
    KEGVFTGAYC INPFDGARVP ILIANYVLYH YGTGAVMGVP AHDERDFEFA 350
    HKYNLPIKVV IYPAQDKEIR VEDMKEAYTA DGIMVHSGPF DGSPNRQGIK 400
    KVIKYAEEKG IGKGIVNYRL RDWLISRQRY WGTPIPIVYC EKCGTVPVPE 450
    DQLPVILPTD VAFKPTGESP LKGRPDFVHT TCPQCGGPAQ RETDTMDTFV 500
    DSSWYYLRYT SSRDTEYAWD KNKADRWMNV DQYIGGVEHA ILHLLYSRFF 550
    TKVFYDLGLV NVQEPFENLL TQGMVLKDGS KMSKSKGNVV SPEEIIDRYG 600
    ADTARMFILF AAPPERDLEW SDRGVEGSHR FLNRVWRLVY SLKDEVAGAP 650
    AISSVNAYVG VHKEMRRLTH YAIKKVTEDV SGRFNFNTAI STIMELVNGI 700
    YTYRDKVAAV ERDTAVLAEA VNSTIILLAP FAPHIAEELW SATGHQGSVH 750
    KQPWLTFDSA ALVEDEVEVA VQINGKVRER LNIPANMKPA EMQQYLMDME 800
    SVKILIGDKQ IVKIIPVPGK LLNIVVK 827
    Length:827
    Mass (Da):94,352
    Last modified:May 1, 2007 - v1
    Checksum:i5406E91E3D9A354D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO51025.1.
    RefSeqiYP_001113850.1. NC_009253.1.

    Genome annotation databases

    EnsemblBacteriaiABO51025; ABO51025; Dred_2515.
    GeneIDi4956110.
    KEGGidrm:Dred_2515.
    PATRICi21731389. VBIDesRed82656_2751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO51025.1 .
    RefSeqi YP_001113850.1. NC_009253.1.

    3D structure databases

    ProteinModelPortali A4J7H2.
    SMRi A4J7H2. Positions 3-762.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349161.Dred_2515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO51025 ; ABO51025 ; Dred_2515 .
    GeneIDi 4956110.
    KEGGi drm:Dred_2515.
    PATRICi 21731389. VBIDesRed82656_2751.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DRED349161:GHP6-2586-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MI-1.

    Entry informationi

    Entry nameiSYL_DESRM
    AccessioniPrimary (citable) accession number: A4J7H2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3