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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei584ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRED349161:G1G8H-2708-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Dred_2515
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
Proteomesi
  • UP000001556 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347501 – 827Leucine--tRNA ligaseAdd BLAST827

Proteomic databases

PRIDEiA4J7H2

Interactioni

Protein-protein interaction databases

STRINGi349161.Dred_2515

Structurei

3D structure databases

ProteinModelPortaliA4J7H2
SMRiA4J7H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi581 – 585"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4J7H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEHYDFKEI EKKWQEDWNK ENTYQVPDFS ERPKYYCLEM FPYPSGKLHM
60 70 80 90 100
GHVRNYSIGD VVARFKTMQG YDVLHPMGWD AFGLPAENAA IKHGIAPATW
110 120 130 140 150
TWDNIAHMRS QLKQLGLSYD WNREVATCHT EYYKWGQWLF LQLYKKGLCY
160 170 180 190 200
KKHARVNWCP DCATVLANEQ VVDGACERCS AVVEQKELDQ WFFRITEYAQ
210 220 230 240 250
RLLNDLKLLK GWPDKVKIMQ ENWIGRSEGA ELTFQVEGSD ESITVFTTRP
260 270 280 290 300
DTVYGVSYMV LAPEHPLVAK LIAGRPQEAE VIGFVNRVNK LTELDRTSSD
310 320 330 340 350
KEGVFTGAYC INPFDGARVP ILIANYVLYH YGTGAVMGVP AHDERDFEFA
360 370 380 390 400
HKYNLPIKVV IYPAQDKEIR VEDMKEAYTA DGIMVHSGPF DGSPNRQGIK
410 420 430 440 450
KVIKYAEEKG IGKGIVNYRL RDWLISRQRY WGTPIPIVYC EKCGTVPVPE
460 470 480 490 500
DQLPVILPTD VAFKPTGESP LKGRPDFVHT TCPQCGGPAQ RETDTMDTFV
510 520 530 540 550
DSSWYYLRYT SSRDTEYAWD KNKADRWMNV DQYIGGVEHA ILHLLYSRFF
560 570 580 590 600
TKVFYDLGLV NVQEPFENLL TQGMVLKDGS KMSKSKGNVV SPEEIIDRYG
610 620 630 640 650
ADTARMFILF AAPPERDLEW SDRGVEGSHR FLNRVWRLVY SLKDEVAGAP
660 670 680 690 700
AISSVNAYVG VHKEMRRLTH YAIKKVTEDV SGRFNFNTAI STIMELVNGI
710 720 730 740 750
YTYRDKVAAV ERDTAVLAEA VNSTIILLAP FAPHIAEELW SATGHQGSVH
760 770 780 790 800
KQPWLTFDSA ALVEDEVEVA VQINGKVRER LNIPANMKPA EMQQYLMDME
810 820
SVKILIGDKQ IVKIIPVPGK LLNIVVK
Length:827
Mass (Da):94,352
Last modified:May 1, 2007 - v1
Checksum:i5406E91E3D9A354D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA Translation: ABO51025.1
RefSeqiWP_011878823.1, NC_009253.1

Genome annotation databases

EnsemblBacteriaiABO51025; ABO51025; Dred_2515
KEGGidrm:Dred_2515

Similar proteinsi

Entry informationi

Entry nameiSYL_DESRM
AccessioniPrimary (citable) accession number: A4J7H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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